MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3858 to 3907 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1929	enigma protein; lim domain protein. [refseq;acc:nm_005451]	Divided	219.753	217.574	1.01001
1930	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]		196.964	198.935
	golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]	Subtracted	211.633	213.703	2.07
1931	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
	eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	Divided	219.753	217.574	1.01001
1932	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]		196.965	198.936
	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	Subtracted	211.632	213.702	2.07
1933	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]		211.633	213.703
	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	Divided	215.667	217.82	1.00998
1934	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]		224.264	222.055	1.00995
	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]	Subtracted	211.633	213.703	2.07
1935	abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	Divided	218.43	216.279	1.00995
	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]	Subtracted	211.633	213.703	2.07
1936	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]		211.632	213.702
	creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	Divided	198.3	196.347	1.00995
1937	quaking isoform 6. [sptrembl;acc:q9p0x9]		218.43	216.279
	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303]	Subtracted	211.633	213.703	2.07
1938	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]
	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	Divided	198.293	196.341	1.00994
1939	e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	Subtracted	219.26	217.193	2.067
	peptidyl prolyl isomerase h; cyclophilin h. [refseq;acc:nm_006347]	Divided	198.258	196.319	1.00988
1940	creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]		198.19	196.252
	mitochondrial ribosomal protein l24. [refseq;acc:nm_024540]	Subtracted	219.26	217.193	2.067
1941	65 kda yes-associated protein (yap65). [swissprot;acc:p46937]
	prp18 pre-mrna processing factor 18 homolog. [refseq;acc:nm_003675]	Divided	198.258	196.319	1.00988
1942	9 kda protein. [swissprot;acc:p13994]	Subtracted	219.26	217.193	2.067
	j domain protein c21orf55. [swissprot;acc:q9nx36]	Divided	198.257	196.319	1.00987
1943	collagen alpha 3(iv) chain precursor (goodpasture antigen). [swissprot;acc:q01955]	Subtracted	219.261	217.195	2.066
	megf11 protein. [refseq;acc:nm_032445]	Divided	224.34	222.147	1.00987
1944	collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	Subtracted	219.26	217.194	2.066
	megf10 protein. [refseq;acc:nm_032446]	Divided	224.341	222.148	1.00987
1945	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]		224.343	222.151
	transcriptional co-activator with pdz-binding motif (taz). [refseq;acc:nm_015472]	Subtracted	219.26	217.194	2.066
1946	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	Divided	214.234	212.142	1.00986
	wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [swissprot;acc:q9y6w5]	Subtracted	214.611	212.546	2.065
1947	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	Divided	125.845	127.083	1.00984
	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	Subtracted	214.611	212.546	2.065
1948	15 kda selenoprotein precursor. [swissprot;acc:o60613]	Divided	214.522	212.432	1.00984
	wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [swissprot;acc:q92558]	Subtracted	214.611	212.546	2.065
1949	rest corepressor. [refseq;acc:nm_015156]
	rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062]	Divided	218.794	216.663	1.00984
1950	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	Subtracted	211.62	213.683	2.063
	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Divided	215.847	213.747	1.00982
1951	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]		205.876	203.873
	zasp protein (fragment). [sptrembl;acc:q9y4z3]	Subtracted	219.267	217.207	2.06
1952	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	Divided	211.647	213.724	1.00981
	receptor protein-tyrosine kinase erbb-4 precursor (ec 2.7.1.112) (p180erbb4) (tyrosine kinase-type cell surface receptor her4). [swissprot;acc:q15303]	Subtracted	225.019	222.969	2.05
1953	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]		180.409	182.459
	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	Divided	125.912	127.146	1.0098
1954	2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	Subtracted	225.019	222.969	2.05

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.