MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 194 to 243 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
49	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Ranked	133	105	1.26667
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	Rooted	27.7254	44.0299	1.58807
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Measured	779.167	1390.33	1.78438
50	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Ranked	133	105	1.26667
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Rooted	27.7254	44.0299	1.58807
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Measured	779.167	1390.33	1.78438
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Squared	28994.2	17134.8	1.69212
51	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Rooted	27.7254	44.0299	1.58807
	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	Measured	779.167	1390.33	1.78438
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Ranked	133	105	1.26667
52	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	Measured	779.167	1390.33	1.78438
	neuralized-like. [refseq;acc:nm_004210]	Rooted	27.9107	44.1656	1.58239
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Squared	28994.2	17134.8	1.69212
53	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	Measured	779.167	1390.33	1.78438
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Rooted	30.8986	46.4619	1.50369
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Squared	28994.2	17134.8	1.69212
	transcription factor jun-b. [swissprot;acc:p17275]	Ranked	201.144	158.868	1.26611
54	deltex 2. [refseq;acc:nm_020892]	Measured	1618.84	2651.88	1.63814
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Squared	219048	129762	1.68808
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Rooted	40.0958	58.7986	1.46645
	transcription factor jun-d. [swissprot;acc:p17535]	Ranked	200.941	158.941	1.26425
55	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	Measured	1629.21	2662.12	1.63399
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Squared	219048	129762	1.68808
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Rooted	41.6734	28.9323	1.44038
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Ranked	320.927	254.434	1.26134
56	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Rooted	41.6851	28.9509	1.43986
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Ranked	266.856	336.233	1.25998
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Squared	219048	129762	1.68808
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	Measured	1631.67	2664.55	1.63302
57	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Ranked	266.856	336.233	1.25998
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	Measured	1631.67	2664.55	1.63302
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Squared	219048	129762	1.68808
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Rooted	41.6879	28.9554	1.43973
58	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Ranked	266.863	336.191	1.25979
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Measured	1631.67	2664.55	1.63302
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Squared	219048	129762	1.68808
	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Rooted	41.6969	28.9696	1.43933
59	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Ranked	266.863	336.19	1.25978
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Squared	219048	129762	1.68808
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Measured	1631.67	2664.55	1.63302
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Rooted	37.2205	52.2064	1.40262
60	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	4489.19	2765.82	1.6231
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Ranked	266.864	336.184	1.25976
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Squared	219048	129762	1.68808
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Rooted	35.6294	49.8119	1.39806
61	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Measured	4489.19	2765.82	1.6231
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Ranked	266.864	336.182	1.25975
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Rooted	43.4291	31.7159	1.36932

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.