MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 451 to 500 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	network_comparison	green
226	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	0	658.544	1.15165	758.411
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	1	9035	1.24114	7279.6
227	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]
	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	0	424.258	1.14972	369.011
228	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	1	9035	1.24114	7279.6
	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	0	4089.65	1.14835	4696.36
229	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]		320.752	1.14829	368.317
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	1	9035	1.24114	7279.6
230	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	0	1498.17	1.14713	1718.6
231	alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]		2017.91	1.14705	1759.22
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	1	9035	1.24114	7279.6
232	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	0	1663.73	1.14579	1906.28
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	1	9035	1.24114	7279.6
233	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	0	348.823	1.14538	399.534
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	1	9035	1.24114	7279.6
234	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]		5181.2	1.23728	6410.58
	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	0	5202.89	1.14333	4550.64
235	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]		1612.86	1.14326	1843.92
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	1	5181.2	1.23728	6410.58
236	peroxisomal acyl-coenzyme a thioester hydrolase 2a (ec 3.1.2.2) (peroxisomal long-chain acyl-coa thioesterase 2) (zap128). [swissprot;acc:p49753]	0	2715.75	1.1426	3103.01
	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	1	4723.53	1.23392	5828.46
237	p28 ing5. [refseq;acc:nm_032329]	0	2551.23	1.13707	2243.69
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	1	4567.04	1.23301	5631.2
238	casein kinase i alpha s-like. [refseq;acc:nm_145203]	0	2198.47	1.13678	1933.94
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	1	27642.5	1.23182	22440.4
239	carboxypeptidase b precursor. [refseq;acc:nm_020361]		7711.38	1.23071	6265.8
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	0	382.142	1.13666	434.366
240	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	1	7711.36	1.23071	6265.79
	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	0	1475.83	1.13575	1676.18
241	keratin associated protein 9.2. [refseq;acc:nm_031961]		1225.47	1.13574	1079.01
	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	1	7711.31	1.23071	6265.76
242	max protein. [swissprot;acc:p25912]		4640.26	1.22943	5704.87
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	0	729.216	1.13524	642.343
243	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	1	4246.95	1.22652	5208.98
	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	0	1225.09	1.13502	1079.36
244	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	1	4250.14	1.22614	5211.25
245	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]		4251.65	1.22595	5212.33
	keratin associated protein 1.5. [refseq;acc:nm_031957]	0	1225.09	1.13502	1079.36
246	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	1	4252.66	1.22583	5213.05
	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	0	1225.09	1.13502	1079.36
247	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	1	6416.68	1.22574	7865.15
248	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	0	1225.09	1.135	1079.37
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	1	6417.18	1.22477	7859.6
249	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	0	1225.08	1.135	1079.37
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	1	6417.18	1.22477	7859.59
250	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	0	1225.08	1.135	1079.37
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	1	6417.18	1.22477	7859.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.