MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 19268 in total

Value Type  : Ranked

Rank	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	High confidence	1	215	322	1.49767
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Subtracted	Low confidence	0	22286	13216	9070
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		High confidence
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Divided	Low confidence	1	318	240	1.325
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Subtracted					78
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		High confidence		288.754	212.554	76.2
8	hbs1-like. [refseq;acc:nm_006620]	Divided			215	322	1.49767
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		Low confidence	0	22286	13216	1.68629
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Subtracted	High confidence				9070
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]			1	288	362	74
	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	Divided		0	11525	21888	1.89918
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]		Low confidence	1	318	240	1.325
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Subtracted			305.472	247.246	58.226
	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]			0	10889.4	19873	8983.6
9	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided		1	58	44	1.31818
	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted			305.399	247.213	58.186
	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]			0	22422	14964	7458
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		High confidence		22286	13216	9070
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Divided	Low confidence				1.68629
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Subtracted	High confidence	1	288	362	74
	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	Divided		0	11525	21888	1.89918
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]			1	212	309	1.45755
10	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]			0	7509.39	14178.1	1.88805
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		Low confidence		22286	13216	1.68629
	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Subtracted		1	305.303	247.169	58.134
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Divided			58	44	1.31818
	protein x 0004. [refseq;acc:nm_016301]		High confidence		212	309	1.45755
	ptd016 protein. [refseq;acc:nm_016125]	Subtracted	Low confidence	0	18050	11234	6816
	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]		High confidence		20989	12479	8510
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]			1	288	362	74
11	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	Divided	Low confidence	0	13730.5	8257	1.66289
	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]			1	37.318	28.4944	1.30966
	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	Subtracted	High confidence	0	12170.7	20670.6	8499.9
	db83 protein. [swissprot;acc:p57088]			1	288	362	74
	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Divided		0	11627	6248	1.86092
	rad50-interacting protein 1. [refseq;acc:nm_021930]			1	337	232	1.45259
	serpin b12. [swissprot;acc:q96p63]	Subtracted	Low confidence	0	14604.2	21138.6	6534.4
	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]			1	304.548	246.824	57.724
12	anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	Divided		0	3190	1933	1.65028
	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]		High confidence		9429.18	5208.84	1.81023
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Subtracted		1	266.856	336.233	69.377
	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]		Low confidence	0	14592	21113.7	6521.7
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	High confidence	1	337	232	1.45259
	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	Subtracted		0	19403	11267	8136
	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]		Low confidence	1	304.359	246.737	57.622
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Divided			37.3475	28.5242	1.30933
13	dystrophin. [swissprot;acc:p11532]	Subtracted	High confidence	0	10232.5	18054.8	7822.3
	fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344]		Low confidence		20324.1	14746.1	5578
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]		High confidence	1	266.856	336.233	69.377
	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	Divided		0	5210.5	9264.5	1.77804

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.