MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	Network Comparison Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 66312 in total

Filtered  : 1

Rank	Value Type	Hugo	Network Comparison Type	description	Interaction Map	network_comparison	red	green
60	Ranked	GNG8	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	High confidence	1.25976	266.864	336.184
		LENG4	Subtracted	malignant cell expression-enhanced gene/tumor progression-enhanc. [refseq;acc:nm_024298]	Low confidence	20.635	211	231.635
	Squared	C1GALT1		core1 udp-galactose:n-acetylgalactosamine-alpha-r beta 1,3-galac. [refseq;acc:nm_020156]		16178.9	73677.6	57498.7
		MAGEA6	Divided	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	High confidence	1.68808	219048	129762
		PPP1R2	Subtracted	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]		66737	192904	126167
		PSCD2	Divided	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Low confidence	1.29425	92930.5	71802.4
	Rooted	no value		cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]		1.11478	59.2532	66.0541
		MAGEC1	Subtracted	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	High confidence	16.623	137.446	120.823
		SON	Divided	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]		1.39806	35.6294	49.8119
		TEX28P2	Subtracted	testis-specific protein tex28. [swissprot;acc:o15482]	Low confidence	7.4602	51.7058	59.166
61	Measured	ARRB2		beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	High confidence	3832	6475.5	10307.5
		HOXB5	Divided	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Low confidence	1.13635	15464.1	17572.7
		JUND	Subtracted	transcription factor jun-d. [swissprot;acc:p17535]		1065.74	6614.51	7680.25
		PYGB	Divided	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	High confidence	1.6231	4489.19	2765.82
	Ranked	APBA1	Subtracted	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Low confidence	20.341	229.144	208.803
		FOSB	Divided	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]		1.10831	202.792	182.974
		GNG5		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	High confidence	1.25975	266.864	336.182
		KCND3	Subtracted	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]		58.394	269.248	327.642
	Squared	NCDN		neurochondrin. [refseq;acc:nm_014284]	Low confidence	16178.9	73677.6	57498.7
		NDN	Divided	necdin. [swissprot;acc:q99608]	High confidence	1.68808	219048	129762
		PPP1R2P9	Subtracted	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]		66684	192779	126095
		PSCD3	Divided	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Low confidence	1.29422	92920.4	71796.4
	Rooted	GOSR2	Subtracted	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]		7.4602	51.7058	59.166
		KCNIP1	Divided	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	High confidence	1.36932	43.4291	31.7159
		MAGEA4	Subtracted	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		16.623	137.446	120.823
		SMYD2	Divided	set and mynd domain containing 2; hskm-b protein; zinc finger, mynd domain containing 14. [refseq;acc:nm_020197]	Low confidence	1.11478	59.2532	66.0541
62	Measured	ARRB1	Subtracted	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	High confidence	3832	6475.5	10307.5
		HOXA5	Divided	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Low confidence	1.13635	15464.1	17572.7
		JUNB	Subtracted	transcription factor jun-b. [swissprot;acc:p17275]		1065.34	6613.42	7678.76
		PYGL	Divided	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	High confidence	1.6231	4489.19	2765.82
	Ranked	FOS	Subtracted	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Low confidence	20.072	202.802	182.73
		FOSL1	Divided	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		1.10804	202.79	183.017
		GNG10		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	1.25974	266.865	336.181
		KCND1	Subtracted	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]		58.371	269.23	327.601
	Squared	BNC1		zinc finger protein basonuclin. [swissprot;acc:q01954]	Low confidence	15083.7	105225	90141.3
		MAGED1	Divided	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	High confidence	1.68808	219048	129762
		PSCD4		cytohesin 4. [swissprot;acc:q9uia0]	Low confidence	1.29219	92262.9	71400.2
		RRS1	Subtracted	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	High confidence	65496	189976	124480
	Rooted	no value		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		16.623	137.446	120.823
		BACH1		transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Low confidence	7.4298	79.2778	86.7076
		KCNIP4	Divided	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	High confidence	1.36847	43.4519	31.7522
		SMYD1		set and mynd domain containing protein 1. [sptrembl;acc:q8nb12]	Low confidence	1.11478	59.2532	66.0541
63	Measured	no value		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		1.13635	15464.1	17572.7
		MYO15A		myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	High confidence	1.6231	4489.19	2765.82
		RRAGB	Subtracted	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Low confidence	1062.5	10618.8	11681.3
		SPATA6		spermatogenesis associated 6. [refseq;acc:nm_019073]	High confidence	3832	6475.5	10307.5
	Ranked	no value	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		1.25973	266.865	336.178
			Subtracted	jun dimerization protein. [refseq;acc:nm_130469]	Low confidence	20.072	202.802	182.73
		NFYC		nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	High confidence	56.223	260.532	204.309
		RBM7	Divided	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Low confidence	1.10749	265.688	239.902

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.