MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 325 to 374 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
163	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Subtracted	133	28	105
	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	Divided	209.299	1.19058	249.187
164	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	ARRB1	Subtracted	133	28	105
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6	Divided	209.299	1.19058	249.187
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2
	spermatogenesis associated 6. [refseq;acc:nm_019073]	SPATA6	Subtracted	133	28	105
166	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG	Divided	209.299	1.19058	249.187
	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	NEUROD4	Subtracted	312	28	284
167	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	AMPD2		133		105
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	GAD1	Divided	209.299	1.19058	249.187
168	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	CHD5	Subtracted	312	28	284
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	no value	Divided	82.5916	1.18722	98.0548
169	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3
	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	CDK2AP1	Subtracted	312	28	284
170	huntingtin interacting protein c. [refseq;acc:nm_012272]	PRPF40B		227.971	27.554	200.417
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	TIA1	Divided	227.199	1.17894	192.715
171	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	TIAL1		227.202	1.17829	192.823
	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	TRPC4	Subtracted	201.478	27.306	228.784
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	TIPRL	Divided	174.667	1.17685	205.556
	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	TBC1D10A	Subtracted	201.515	27.237	228.752
173	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	TRPC5
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	SNRPD1	Divided	227.032	1.17599	193.056
174	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	DGCR14		335	1.17133	286
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	LUC7L2	Subtracted	228.1	27.132	200.968
175	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	COPS3	Divided	199.949	1.17123	234.187
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	LUC7L	Subtracted	228.085	27.079	201.006
176	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	POLE4	Divided	275.754	1.1689	235.908
	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	EIF5	Subtracted	271.016	26.849	244.167
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	NCBP2L	Divided	229.406	1.1663	196.695
	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	SIN3A	Subtracted	241.07	26.81	267.88
178	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	DENR
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value	Divided	226.887	1.1652	194.72
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]			226.884	1.16476	194.79
	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	PAH	Subtracted	227.357	26.793	254.15
180	pp3111 protein. [refseq;acc:nm_022156]	DUS1L
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP	Divided	256.228	1.16474	298.438
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		229.818	1.16294	267.265
	syntaxin 18. [swissprot;acc:q9p2w9]	STX18	Subtracted	227.357	26.793	254.15
182	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	HAT1	Divided	277.546	1.15422	240.461
	rd protein. [swissprot;acc:p18615]	no value	Subtracted	227.357	26.793	254.15
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2	Divided	228.306	1.153	198.011
	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	GSTO1	Subtracted	227.357	26.793	254.15
184	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	AIG1
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	OSR1	Divided	274.027	1.15239	237.79
185	adiponectin receptor 2. [refseq;acc:nm_024551]	ADIPOR2		281.582	1.14292	246.371
	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	ATP5F1	Subtracted	227.357	26.793	254.15
186	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	FLNB	Divided	226.582	1.14179	198.444
	j domain containing protein 1. [swissprot;acc:q9ukb3]	DNAJC12	Subtracted	227.357	26.793	254.15
187	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	REV1	Divided	226.582	1.14179	198.444
	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	SNX13	Subtracted	227.357	26.793	254.15

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.