MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 118 to 167 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
59	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Divided	1631.67	2664.55	1.63302
60	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		4489.19	2765.82	1.6231
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Subtracted	16771.5	12889.1	3882.4
61	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		6475.5	10307.5	3832
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Divided	4489.19	2765.82	1.6231
62	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Subtracted	6475.5	10307.5	3832
	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Divided	4489.19	2765.82	1.6231
63	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Subtracted	6475.5	10307.5	3832
64	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Divided	4489.19	2765.82	1.6231
65	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	Subtracted	22515.5	18702.6	3812.9
	neuralized-like. [refseq;acc:nm_004210]	Divided	1657.68	2690.25	1.6229
66	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	Subtracted	17757.5	14008	3749.5
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Divided	1991.03	3221.38	1.61795
67	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		6475.5	10307.5	1.59177
	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	Subtracted	17756.5	14007.3	3749.2
68	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Divided	6475.5	10307.5	1.59177
	cyclin g2. [swissprot;acc:q16589]	Subtracted	17738.6	13995.7	3742.9
69	cyclin g1 (cyclin g). [swissprot;acc:p51959]		17738.5	13995.6
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Divided	6475.5	10307.5	1.59177
70	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Subtracted	17738.5	13995.7	3742.8
71	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Divided	4556.78	2945.26	1.54716
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	Subtracted	17738.5	13995.7	3742.8
72	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]		17710.9	13977.7	3733.2
	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	Divided	4556.79	2945.28	1.54715
73	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]		4556.83	2945.38	1.54711
	serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873]	Subtracted	22268.8	18560.4	3708.4
74	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		20446.1	24136.4	3690.3
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	Divided	4556.99	2945.8	1.54694
75	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Subtracted	20446.1	24136.4	3690.3
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Divided	1920.75	2907.43	1.5137
76	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Subtracted	20446.1	24136.4	3690.3
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	Divided	4599.26	3058.57	1.50373
77	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Subtracted	20446.1	24136.4	3690.3
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	Divided	4612.39	3093.6	1.49095
78	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		4800.81	7132.71	1.48573
	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Subtracted	20446.1	24136.4	3690.3
79	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Divided	3074.57	4567.51	1.48558
80	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Subtracted	20446.1	24136.4	3690.3
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Divided	4133.47	5945.32	1.43834
81	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Subtracted	20446.1	24136.4	3690.3
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	Divided	4136.36	5943.56	1.43691
82	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Subtracted	20446.1	24136.4	3690.3
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Divided	4172.91	5954.48	1.42694
83	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	Subtracted	21644.2	18098.7	3545.5
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Divided	4932.27	7033.29	1.42597
84	jun dimerization protein. [refseq;acc:nm_130469]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.