MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1327 to 1376 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
664	pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	Subtracted	6231.31	6933.9	702.59
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	Divided	6374.65	7145.59	1.12094
665	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	Subtracted	4108.15	4808.93	700.78
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Divided	6374.65	7145.59	1.12094
666	epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	Subtracted	6781.05	7480.15	699.1
	tbc1 domain family member 5. [swissprot;acc:q92609]	Divided	6374.65	7145.59	1.12094
667	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	Subtracted	10075.5	9377.75	697.75
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	Divided	6374.65	7145.59	1.12094
668	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	Subtracted	10075.5	9377.75	697.75
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Divided	6374.65	7145.59	1.12094
669	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	Subtracted	10075.5	9377.75	697.75
	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	Divided	6374.65	7145.59	1.12094
670	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	Subtracted	10075.5	9377.75	697.75
	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	Divided	6374.65	7145.59	1.12094
671	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	Subtracted	10075.5	9377.75	697.75
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	Divided	6374.65	7145.59	1.12094
672	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]	Subtracted	10075.5	9377.75	697.75
	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	Divided	6374.65	7145.59	1.12094
673	fibulin-1 precursor. [swissprot;acc:p23142]	Subtracted	8550.79	9248.06	697.27
	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Divided	6933.17	7766.54	1.1202
674	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	Subtracted	6000.23	6696.89	696.66
	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	Divided	5549.2	6215.42	1.12006
675	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]
	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	Subtracted	6000.23	6696.89	696.66
676	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]
	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	Divided	5549.2	6215.42	1.12006
677	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Subtracted	4024.4	4719.35	694.95
	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]	Divided	5549.2	6215.42	1.12006
678	cytoplasmic protein nck1 (nck adaptor protein 1) (sh2/sh3 adaptor protein nck-alpha). [swissprot;acc:p16333]	Subtracted	6784.67	7475.48	690.81
	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	6938.22	7770.65	1.11998
679	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]		6503.1	7282.94	1.11992
	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	Subtracted	4910.6	5600.61	690.01
680	adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	Divided	6503.03	7282.5	1.11986
	galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	Subtracted	4910.6	5600.61	690.01
681	ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304]	Divided	7170.83	8029.64	1.11976
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	Subtracted	4910.6	5600.61	690.01
682	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]		5560.06	6248.27	688.21
	syntaxin 12. [refseq;acc:nm_177424]	Divided	5552.92	6217.59	1.1197
683	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	Subtracted	3751.3	4431.34	680.04
	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	Divided	7139.5	7994.06	1.11969
684	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]		4359.82	4880.99	1.11954
	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	Subtracted	5575.18	6254.85	679.67
685	metaxin 1. [swissprot;acc:q13505]	Divided	9327.58	10442.2	1.1195
	step ii splicing factor slu7. [refseq;acc:nm_006425]	Subtracted	5575.18	6254.85	679.67
686	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	Divided	6920.69	7747.63	1.11949
	uba/ubx 33.3 kda protein. [swissprot;acc:q04323]	Subtracted	6562.98	7242.37	679.39
687	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Divided	6920.71	7747.65	1.11949
	ero1-like. [refseq;acc:nm_014584]	Subtracted	6562.98	7242.37	679.39
688	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Divided	6920.67	7747.6	1.11949
	retinoblastoma-like protein 1 (107 kda retinoblastoma-associated protein) (prb1) (p107). [swissprot;acc:p28749]	Subtracted	6311.83	6989.6	677.77

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.