MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	red	green	network_comparison	Filtered

Results: HTML CSV LaTeX

Showing element 551 to 600 of 77072 in total

Rank	Value Type	description	Network Comparison Type	Interaction Map	red	green	network_comparison	Filtered
18	Measured	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	Subtracted	Low confidence	859	58	801	0
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	High confidence	677.5	1865.5	2.75351	1
	Ranked	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]			185.678	245.247	1.32082
		early hematopoietic zinc finger. [refseq;acc:nm_015461]		Low confidence	5850.23	8903.28	1.52187	0
		elongation of very long chain fatty acids protein 2. [swissprot;acc:q9nxb9]	Subtracted		16116.4	11505	4611.4
		fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]		High confidence	7509.39	14178.1	6668.71
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]			266.865	336.181	69.316	1
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Divided		22286	13216	1.68629	0
		jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]		Low confidence	305.303	247.169	1.2352	1
		protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Subtracted		273.188	232.49	40.698
	Squared	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	Divided	High confidence	439.709	0.52284	841.001	0
		camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]		Low confidence	2.31976	0.0854438	27.1495
		clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	Subtracted	High confidence	43393.5	56658.6	13265.1
		homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]		Low confidence	122475	159767	37292	1
		melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		High confidence	219048	129762	89286
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	Low confidence	332411	473408	1.42416
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		High confidence	108.641	823.69	7.58176
		ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Subtracted	Low confidence	9955.21	18724.4	8769.19	0
	Rooted	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	Divided	High confidence	9.20014	60.0707	6.52932
		camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]		Low confidence	9.94987	4.3589	2.28266
		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	High confidence	203.673	182.638	21.035	1
		dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Divided		21.4476	36.9459	1.72261
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Subtracted	Low confidence	0	9.43398	9.43398	0
		protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Divided		44.4168	55.937	1.25937	1
		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	Subtracted	High confidence	12.4097	0	12.4097	0
		trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]		Low confidence	32.2231	47.928	15.7049	1
19	Measured	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Divided	High confidence	305.45	26.1599	11.6763	0
				Low confidence	3032.56	3915.4	1.29112	1
		cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Subtracted	High confidence	24250	18164.9	6085.1
		dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]			1593	2804	1211	0
		fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	Divided	Low confidence	153	662	4.3268
		fos-related antigen 2. [swissprot;acc:p15408]	Subtracted		3205.98	2407.27	798.71
		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]			15464.1	17572.7	2108.6	1
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	High confidence	677.5	1865.5	2.75351
	Ranked	alpha 2 globin. [refseq;acc:nm_000517]	Subtracted	Low confidence	11486.2	15987.1	4500.9	0
		glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Divided	High confidence	185.678	245.247	1.32082	1
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Subtracted		266.865	336.178	69.313
		histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		Low confidence	188.298	228.509	40.211
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Divided	High confidence	22286	13216	1.68629	0
		nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	Subtracted		4475.84	11083.9	6608.06
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	Low confidence	3208.8	4871.6	1.5182
		trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]			304.548	246.824	1.23387	1
	Squared	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Subtracted		122475	159767	37292
		melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		High confidence	219048	129762	89286
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided		108.641	823.69	7.58176
		nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	Subtracted		10489.8	23426.5	12936.7	0
		potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided	Low confidence	6.25494	141.944	22.6931
		serpin b12. [swissprot;acc:q96p63]		High confidence	23.5744	0.0289898	813.196
		succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	Subtracted	Low confidence	124602	133193	8591
		vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Divided		332411	473408	1.42416	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.