MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Network Comparison Type	Rank	description	Filtered	Value Type	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 19268 in total

Network Comparison Type  : Divided
Value Type  : Ranked

Rank	description	Filtered	Interaction Map	green	red	network_comparison
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	1	High confidence	114	94	1.21277
	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]	0	Low confidence	17562.2	14899.4	1.17872
	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	1		179.639	191.688	1.06707
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	0	High confidence	11493.8	9722.71	1.18216
127	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	1		114	94	1.21277
	scribble. [refseq;acc:nm_015356]	0	Low confidence	11814.4	10041.1	1.1766
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]		High confidence	11119.7	9411.34	1.18152
	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	1	Low confidence	190.88	203.678	1.06705
128	60s ribosomal protein l39. [swissprot;acc:p02404]	0	High confidence	9794.29	11564.4	1.18073
	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	1		114	94	1.21277
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	0	Low confidence	10879.6	9259.51	1.17496
	striatin. [swissprot;acc:o43815]	1		200.796	214.085	1.06618
129	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]			235.572	220.969	1.06609
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	0		10865.5	9248.93	1.17478
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]		High confidence	12058.6	14222.5	1.17945
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	1		114	94	1.21277
130	enigma protein; lim domain protein. [refseq;acc:nm_005451]	0		17069.5	14476.2	1.17914
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	1		114	94	1.21277
	sedlin. [swissprot;acc:o14582]	0	Low confidence	13646	16024.9	1.17433
	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	1		211.529	225.495	1.06602
131	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	0	High confidence	9873.58	8375.43	1.17887
	mitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5) (pred22 protein). [swissprot;acc:q9nyk5]		Low confidence	5609	4793.5	1.17013
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	1	High confidence	242.562	294.053	1.21228
	striatin 4 (zinedin). [swissprot;acc:q9nrl3]		Low confidence	200.825	213.878	1.065
132	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]			206.997	220.268	1.06411
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	0		14027.1	16411.9	1.17001
	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]		High confidence	22389	19048	1.1754
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	1		290	350	1.2069
133	alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	0	Low confidence	13113.5	11236.1	1.16709
	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]		High confidence	8009	6814	1.17537
	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	1	Low confidence	206.997	220.268	1.06411
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]		High confidence	290	350	1.2069
134	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	0		10489.3	12314.9	1.17404
	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	1		290	350	1.2069
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	0	Low confidence	7893.05	9210.38	1.1669
	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	1		205.431	218.561	1.06391
135	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	0	High confidence	10489.3	12314.9	1.17404
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	1		290	350	1.2069
	neuronal protein np25. [swissprot;acc:q9ui15]		Low confidence	205.57	218.66	1.06368
	phosphatidylinositol 4-kinase alpha (ec 2.7.1.67) (pi4-kinase) (ptdins-4-kinase) (pi4k-alpha). [swissprot;acc:p42356]	0		13250	15432.9	1.16475
136	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]		High confidence	10506.8	12335.3	1.17403
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	1		290	350	1.2069
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]		Low confidence	190.854	202.996	1.06362
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	0		13977.2	12024.2	1.16242
137	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]		High confidence	10501	12328.5	1.17403
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]		Low confidence	12965.5	11161.3	1.16165
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	1	High confidence	290	350	1.2069
	testican-3 precursor. [swissprot;acc:q9bq16]		Low confidence	234.389	220.395	1.0635
138	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	0	High confidence	10549.4	12384.7	1.17397
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	1		234.204	194.372	1.20493

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.