MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 830 to 879 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

Rank	description	Network Comparison Type	Filtered	red	green	network_comparison
208	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	Divided	0	11846.3	10638.4	1.11354
	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	Subtracted		19939	18778	1161
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Divided	1	285.684	252.234	1.13261
209	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	Subtracted		240.782	265.717	24.935
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Divided		285.684	252.234	1.13261
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]		0	775	696	1.11351
	tigger transposable element derived 6. [refseq;acc:nm_030953]	Subtracted		12360	11200.2	1159.8
210	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Divided	1	285.684	252.234	1.13261
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]		0	17144.8	15405.6	1.11289
	rna-binding protein. [refseq;acc:nm_019027]	Subtracted	1	237.302	212.41	24.892
	tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208]		0	12364.7	11207.7	1157
211	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]		1	237.302	212.41	24.892
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Divided		285.684	252.234	1.13261
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]		0	10367	9320.25	1.11231
	tigger transposable element derived 1; jerky (mouse) homolog-like. [refseq;acc:nm_145702]	Subtracted		12364.8	11207.9	1156.9
212	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	Divided	1	285.684	252.234	1.13261
	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]	Subtracted	0	12394.7	11240.2	1154.5
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	Divided		18241.7	16405	1.11196
	ns1-associated protein 1. [refseq;acc:nm_006372]	Subtracted	1	237.302	212.41	24.892
213	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]		0	11867.6	13019	1151.4
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]		1	237.302	212.41	24.892
	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	Divided		210.693	186.95	1.127
	protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]		0	9379.47	8436.39	1.11179
214	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		1	191.644	170.192	1.12605
	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	Subtracted		241.282	266.12	24.838
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	Divided	0	7621.99	8473.85	1.11176
	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]	Subtracted		14898.9	16041.6	1142.7
215	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]		1	237.292	212.457	24.835
	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	Divided		112	126	1.125
	myosin vi. [swissprot;acc:q9um54]		0	10121.5	11250.5	1.11154
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Subtracted		7955.61	6817.49	1138.12
216	high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]			5677.96	4546.87	1131.09
	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	Divided		10559.7	11732	1.11102
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]		1	112	126	1.125
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Subtracted		226.471	201.769	24.702
217	60s ribosomal protein l26. [swissprot;acc:q02877]			242.326	267.008	24.682
	baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]	Divided	0	7101.79	6406.18	1.10858
	dj579f20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1). [sptrembl;acc:q9nqj4]	Subtracted		5677.89	4547.43	1130.46
	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Divided	1	112	126	1.125
218	60s ribosomal protein l35. [swissprot;acc:p42766]	Subtracted		242.333	266.999	24.666
	high mobility group protein 1-like 10 (hmg-1l10). [swissprot;acc:q9ugv6]		0	5677.86	4547.66	1130.2
	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	Divided		19355	17469.2	1.10795
	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]		1	112	126	1.125
219	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Subtracted		242.339	266.986	24.647
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Divided		112	126	1.125
	myosin vi. [swissprot;acc:q9um54]	Subtracted	0	10121.5	11250.5	1129
	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	Divided		12196.2	11009.7	1.10777
220	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Subtracted	1	242.339	266.986	24.647
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Divided		112	126	1.125
	neurocalcin delta. [swissprot;acc:p29554]		0	13973.6	15473.5	1.10734

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.