MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	Value Type	Rank	Gene	description	green	Interaction Map	Network Comparison Type	red	network_comparison

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Showing element 501 to 550 of 19268 in total

Filtered  : 0
Value Type  : Ranked

Rank	description	green	Interaction Map	Network Comparison Type	red	network_comparison
126	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]	17562.2	Low confidence	Divided	14899.4	1.17872
	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	10489.3	High confidence	Subtracted	12314.9	1825.6
	putative protein-tyrosine phosphatase tpte (ec 3.1.3.48). [swissprot;acc:p56180]	14123.3	Low confidence		15945.5	1822.2
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	11493.8	High confidence	Divided	9722.71	1.18216
127	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	13530.6		Subtracted	11732	1798.6
	dna helicase homolog (fragment). [sptrembl;acc:q9y645]	18475.5	Low confidence		16660.8	1814.7
	scribble. [refseq;acc:nm_015356]	11814.4		Divided	10041.1	1.1766
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	11119.7	High confidence		9411.34	1.18152
128	60s ribosomal protein l39. [swissprot;acc:p02404]	9794.29			11564.4	1.18073
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	10879.6	Low confidence		9259.51	1.17496
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	12965.5		Subtracted	11161.3	1804.2
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	11493.8	High confidence		9722.71	1771.09
129	60s ribosomal protein l39. [swissprot;acc:p02404]	9794.29			11564.4	1770.11
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	10865.5	Low confidence	Divided	9248.93	1.17478
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	12058.6	High confidence		14222.5	1.17945
	piwi-like 2; miwi like. [refseq;acc:nm_018068]	15008.1	Low confidence	Subtracted	13206.7	1801.4
130	enigma protein; lim domain protein. [refseq;acc:nm_005451]	17069.5	High confidence	Divided	14476.2	1.17914
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	13174.5		Subtracted	14922.7	1748.2
	scribble. [refseq;acc:nm_015356]	11814.4	Low confidence		10041.1	1773.3
	sedlin. [swissprot;acc:o14582]	13646		Divided	16024.9	1.17433
131	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	9873.58	High confidence		8375.43	1.17887
	integral membrane protein cii-3b. [sptrembl;acc:o75609]	13204.2		Subtracted	14951.6	1747.4
	mitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5) (pred22 protein). [swissprot;acc:q9nyk5]	5609	Low confidence	Divided	4793.5	1.17013
	transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1]	13277.6		Subtracted	15039.8	1762.2
132	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	10962.4			12716.5	1754.1
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	14027.1		Divided	16411.9	1.17001
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	12622.8	High confidence	Subtracted	10883	1739.8
	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	22389		Divided	19048	1.1754
133	alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	13113.5	Low confidence		11236.1	1.16709
	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	8009	High confidence		6814	1.17537
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	15405.6		Subtracted	17144.8	1739.2
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	13174.5	Low confidence		14922.7	1748.2
134	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	10489.3	High confidence	Divided	12314.9	1.17404
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	15123	Low confidence	Subtracted	16853	1730
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	13890.3	High confidence		12157.6	1732.7
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	7893.05	Low confidence	Divided	9210.38	1.1669
135	bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	10603.2	High confidence	Subtracted	8871.11	1732.09
	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	10489.3		Divided	12314.9	1.17404
	phosphatidylinositol 4-kinase alpha (ec 2.7.1.67) (pi4-kinase) (ptdins-4-kinase) (pi4k-alpha). [swissprot;acc:p42356]	13250	Low confidence		15432.9	1.16475
	serpin b11. [swissprot;acc:q96p15]	15123		Subtracted	16853	1730
136	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	10506.8	High confidence	Divided	12335.3	1.17403
	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	15123	Low confidence	Subtracted	16853	1730
	polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]	11028.8	High confidence		12759.4	1730.6
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	13977.2	Low confidence	Divided	12024.2	1.16242
137	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	10501	High confidence		12328.5	1.17403
	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	21041	Low confidence	Subtracted	19314	1727
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	12965.5		Divided	11161.3	1.16165
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	15123	High confidence	Subtracted	16853	1730
138	beta tubulin 1, class vi. [refseq;acc:nm_030773]	14503.8	Low confidence		12794.3	1709.5
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	10549.4	High confidence	Divided	12384.7	1.17397

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.