MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Rank	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2380 to 2429 of 29840 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
688	retinoblastoma-like protein 1 (107 kda retinoblastoma-associated protein) (prb1) (p107). [swissprot;acc:p28749]	Subtracted	6311.83	6989.6	677.77
689	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	Divided	6920.69	7747.63	1.11949
	retinoblastoma-like protein 2 (130 kda retinoblastoma-associated protein) (prb2) (p130) (rbr-2). [swissprot;acc:q08999]	Subtracted	6311.6	6989.33	677.73
690	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Divided	6920.69	7747.63	1.11949
	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	Subtracted	6257.99	6932.95	674.96
691	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	Divided	6920.69	7747.63	1.11949
	t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	Subtracted	8425.35	7751.57	673.78
692	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Divided	6920.69	7747.63	1.11949
	e-1 enzyme. [refseq;acc:nm_021204]	Subtracted	6603.09	7274.72	671.63
693	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		3199.4	3870.8	671.4
	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]	Divided	7725.1	8647.74	1.11943
694	human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]
	orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406]	Subtracted	6075.55	6746.92	671.37
695	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]		5768.32	6434.78	666.46
	zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]	Divided	7725.1	8647.74	1.11943
696	human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Subtracted	5768.32	6434.78	666.46
697	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
	sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962]	Divided	7105.27	7953.71	1.11941
698	armet protein precursor (arginine-rich protein). [swissprot;acc:p55145]		7101.95	7949.85	1.11939
	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Subtracted	5768.32	6434.78	666.46
699	cellular modulator of immune recognition. [refseq;acc:nm_145021]
	histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	Divided	7101.94	7949.84	1.11939
700	40s ribosomal protein s28. [swissprot;acc:p25112]		7161.14	8015.92	1.11936
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	Subtracted	5768.32	6434.78	666.46
701	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]
	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	Divided	7802.31	8731.82	1.11913
702	sh3-containing grb2-like protein 3 (sh3 domain protein 2c) (een-b2). [swissprot;acc:q99963]		7067.46	7909.27	1.11911
	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	Subtracted	5549.2	6215.42	666.22
703	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]	Divided	6912.56	7735.12	1.11899
	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]	Subtracted	5549.2	6215.42	666.22
704	alpha-nac protein. [sptrembl;acc:q9h009]	Divided	6912.27	7734.68	1.11898
	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	Subtracted	5549.2	6215.42	666.22
705	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]	Divided	6912.09	7734.41	1.11897
	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]	Subtracted	5549.2	6215.42	666.22
706	di-ras2. [refseq;acc:nm_017594]	Divided	6912.08	7734.39	1.11897
	syntaxin 12. [refseq;acc:nm_177424]	Subtracted	5552.92	6217.59	664.67
707	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]		5870.2	6533.39	663.19
	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	Divided	5317.78	5944.25	1.11781
708	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	Subtracted	4775.11	5438.18	663.07
	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	Divided	5317.78	5944.25	1.11781
709	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]	Subtracted	5148.71	5811.74	663.03
	pp1201 protein. [refseq;acc:nm_022152]	Divided	5317.78	5944.25	1.11781
710	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Subtracted	2755.15	2094.3	660.85
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	Divided	5317.78	5944.25	1.11781
711	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Subtracted	2759.61	2099.49	660.12
	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	Divided	5317.78	5944.25	1.11781
712	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Subtracted	2760.28	2100.27	660.01
	sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956]	Divided	5317.78	5944.25	1.11781
713	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	Subtracted	5162.52	5822.47	659.95

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.