MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	Value Type	green	network_comparison	Rank	Gene	Interaction Map	description	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 51 to 100 of 77072 in total

Filtered  : 0
Value Type  : Measured

green	network_comparison	Rank	Interaction Map	description	red	Network Comparison Type
0.00001	3700000	22	Low confidence	carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]	37	Divided
		23		carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [refseq;acc:nm_004267]
	6000000	22	High confidence	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	60
	8200000	20		ero1-like. [refseq;acc:nm_014584]	82
	15400000	95		nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	154
		96		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
	28600000	44	Low confidence	neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]	286
		45		neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]
	36400000	1	High confidence	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	364
			Low confidence
5.56738	35.8425	10		serpin b12. [swissprot;acc:q96p63]	199.549
		11	High confidence
	193.982	168				Subtracted
		280	Low confidence
5.71669	34.8539	11		hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	199.249	Divided
		12	High confidence
	193.532	169				Subtracted
		281	Low confidence
6.50325	20.0687	14	High confidence	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	130.512	Divided
	124.009	258				Subtracted
10.6048	36.1876	9	Low confidence	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]	383.762	Divided
	373.157	166				Subtracted
11.5	1.21739	176		protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	14	Divided
		190	High confidence
	2.5	489				Subtracted
		819	Low confidence
14.3333	1.3721	121	High confidence	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	19.6667	Divided
	5.3334	460				Subtracted
15	14	443		protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	1
	15	16				Divided
17.5166	17.5166	755	Low confidence	jumonji protein. [swissprot;acc:q92833]	0	Subtracted
	1751660	5			0.00001	Divided
17.6611	6.73106	21	High confidence	syntaxin 10 (syn10). [swissprot;acc:o60499]	118.878
	101.217	269				Subtracted
18	18	428		phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	0
	1800000	64			0.00001	Divided
19	1.21053	184	Low confidence	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	23
		195	High confidence
	4	464				Subtracted
		807	Low confidence
	5.21053	18		camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]	99	Divided
	80	483				Subtracted
21	2.09524	50	High confidence	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	44	Divided
	23	407				Subtracted
23.6984	2.03615	64	Low confidence	dna helicase homolog (fragment). [sptrembl;acc:q9y645]	48.2534	Divided
	24.555	713				Subtracted
26.1599	11.6763	18	High confidence	60s ribosomal protein l37a. [swissprot;acc:p12751]	305.45	Divided
		19		25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]
	279.29	114		60s ribosomal protein l37a. [swissprot;acc:p12751]		Subtracted
		115		25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.