MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	Network Comparison Type	green	Interaction Map	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 7460 in total

Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Network Comparison Type	green	Filtered	red	network_comparison
113	sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]	Divided	112.25	0	160	1.42539
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	Subtracted	2833.94		3117.17	283.23
114	60s ribosomal protein l37a. [swissprot;acc:p12751]		26.1599		305.45	279.29
	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]		11466	1	13768.2	2302.2
	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	Divided	472.945	0	671.769	1.4204
	huntingtin interacting protein c. [refseq;acc:nm_012272]		5807.72	1	4300.47	1.35048
115	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Subtracted	26.1599	0	305.45	279.29
	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided	28492	1	21185	1.34491
	pnas-18. [sptrembl;acc:q9bzu3]	Subtracted	11409.6		13680.5	2270.9
	zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782]	Divided	543	0	385	1.41039
116	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]		475		668	1.40632
	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]	Subtracted	1107		1382.5	275.5
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Divided	28492	1	21185	1.34491
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Subtracted	11017.8		13261.9	2244.1
117	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]		891.114	0	1161.88	270.766
	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]		7090.37	1	9276.47	2186.1
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Divided	28492		21185	1.34491
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]		122	0	170.5	1.39754
118	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	Subtracted	7089.65	1	9275.1	2185.45
	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]		593.094	0	324.442	268.652
	methyltransferase like 2. [refseq;acc:nm_018396]	Divided	43		31	1.3871
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		28492	1	21185	1.34491
119	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	Subtracted	15138.2		12998.5	2139.7
	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	Divided	460.2	0	633.85	1.37734
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		28492	1	21185	1.34491
	ubiquitin protein ligase. [refseq;acc:nm_130466]	Subtracted	352.75	0	620	267.25
120	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	6895.98	1	5136.78	1.34247
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	7033.29		4932.27	2101.02
	signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	Divided	359.631	0	494.417	1.37479
	transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3]	Subtracted	551.434		817.81	266.376
121	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	Divided	14.3333		19.6667	1.3721
	jun dimerization protein. [refseq;acc:nm_130469]	Subtracted	7033.29	1	4932.27	2101.02
	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]		1139	0	874	265
	transcription factor jun-b. [swissprot;acc:p17275]	Divided	7488.4	1	5579.18	1.3422
122	casein kinase i alpha s-like. [refseq;acc:nm_145203]	Subtracted	1933.94	0	2198.47	264.53
	fos-related antigen 2. [swissprot;acc:p15408]		7037.11	1	4941.95	2095.16
	high-mobility group 20a. [refseq;acc:nm_018200]	Divided	6893.53		5140.14	1.34112
	sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]		78	0	107	1.37179
123	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		18172.1	1	24260.3	1.33503
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Subtracted	7037.32		4942.49	2094.83
	putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]		1643	0	1905.84	262.84
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	Divided	1681.3		2285.62	1.35944
124	brain protein 16. [refseq;acc:nm_016458]	Subtracted	2418.14		2155.75	262.39
	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		7038.04	1	4944.3	2093.74
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Divided	18168.9		24255.7	1.33501
	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]		2399.76	0	3248.95	1.35386
125	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]	Subtracted	3952.59		3691.15	261.44
	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]		14561.7	1	12471.7	2090
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Divided	18168.9		24255.7	1.33501
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		812.166	0	1095.42	1.34876

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.