MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 4391 to 4440 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
596	Squared	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	34129.6	40434.5	1.18473
	Rooted	cbf1 interacting corepressor. [refseq;acc:nm_004882]	60.0587	65.0057	1.08237
597	Measured	histone h2b.d (h2b/d). [swissprot;acc:q99877]	3946.32	4475.47	1.13409
	Ranked	vav-2 protein. [swissprot;acc:p52735]	212.526	200.212	1.0615
	Squared	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	34129.4	40434.2	1.18473
	Rooted	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	60.0587	65.0057	1.08237
598	Measured	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	3946.32	4475.47	1.13409
	Ranked	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	248.463	234.095	1.06138
	Squared	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	34129.6	40434.5	1.18473
	Rooted	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]	61.2527	66.2644	1.08182
599	Measured	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	3946.32	4475.47	1.13409
	Ranked	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	248.463	234.095	1.06138
	Squared	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	34129.6	40434.5	1.18473
	Rooted	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	138.375	127.926	1.08168
600	Measured	histone h2b.e (h2b/e). [swissprot;acc:q99879]	3946.32	4475.47	1.13409
	Ranked	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	248.463	234.095	1.06138
	Squared	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	34129.6	40434.5	1.18473
	Rooted	trs85 homolog. [swissprot;acc:q9y2l5]	138.375	127.926	1.08168
601	Measured	symplekin. [swissprot;acc:q92797]	15213.4	13418.1	1.1338
	Ranked	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	206.274	218.792	1.06069
	Squared	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	34129.6	40434.5	1.18473
	Rooted	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	138.032	127.651	1.08132
602	Measured	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	4864.66	5514.87	1.13366
	Ranked	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	206.274	218.792	1.06069
	Squared	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	19129.8	22652.9	1.18417
	Rooted	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	138.032	127.651	1.08132
603	Measured	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	4864.66	5514.87	1.13366
	Ranked	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	225.829	212.945	1.0605
	Squared	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]	34071.5	40336.5	1.18388
	Rooted	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	60.0742	64.9418	1.08103
604	Measured	vinculin (metavinculin). [swissprot;acc:p18206]	5958.23	6743.37	1.13177
	Ranked	60s ribosomal protein l15. [swissprot;acc:p39030]	217.862	230.978	1.0602
	Squared	alpha-nac protein. [sptrembl;acc:q9h009]	34069.4	40333	1.18385
	Rooted	step ii splicing factor slu7. [refseq;acc:nm_006425]	60.0742	64.9418	1.08103
605	Measured	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	6143.52	6950.75	1.1314
	Ranked	histone h2b.c (h2b/c). [swissprot;acc:q99880]	247.47	233.441	1.0601
	Squared	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]	34068.1	40330.8	1.18383
	Rooted	sedlin. [swissprot;acc:o14582]	116.061	125.434	1.08076
606	Measured	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	6148.94	6955.76	1.13121
	Ranked	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	247.47	233.441	1.0601
	Squared	di-ras2. [refseq;acc:nm_017594]	34068	40330.7	1.18383
	Rooted	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	116.061	125.434	1.08076
607	Measured	likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235]	14976.4	13246.6	1.13058
	Ranked	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	247.47	233.441	1.0601
	Squared	cytosolic nonspecific dipeptidase (glutamate carboxypeptidase-like protein 1). [swissprot;acc:q96kp4]	26583.8	31468.6	1.18375
	Rooted	bet3 homolog. [swissprot;acc:o43617]	116.061	125.434	1.08076
608	Measured	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	4510.61	5098.74	1.13039
	Ranked	histone h2b. [refseq;acc:nm_175055]	247.47	233.441	1.0601
	Squared	nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570]	24560.6	29071.1	1.18365
	Rooted	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	59.6517	64.4642	1.08068

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.