MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3758 to 3807 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
940	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	Ranked	212.442	205.088	1.03586
	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]	Rooted	62.3618	66.0328	1.05887
	glycerol-3-phosphate dehydrogenase, mitochondrial precursor (ec 1.1.99.5) (gpd-m) (gpdh-m). [swissprot;acc:p43304]	Squared	25108.4	28986.7	1.15446
941	5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]		26005.2	30020.3	1.1544
	caax prenyl protease 1 homolog (ec 3.4.24.-) (prenyl protein-specific endoprotease 1) (farnesylated-proteins converting enzyme 1) (face-1) (zinc metalloproteinase ste24 homolog). [swissprot;acc:o75844]	Measured	4970.21	5455.34	1.09761
	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	Ranked	212.437	205.083	1.03586
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]	Rooted	62.3618	66.0328	1.05887
942	cyclin m2; ancient conserved domain protein 2. [refseq;acc:nm_017649]	Squared	23659.9	27312.6	1.15438
	grancalcin. [swissprot;acc:p28676]	Ranked	212.442	205.088	1.03586
	phosphoglycerate kinase, testis specific (ec 2.7.2.3). [swissprot;acc:p07205]	Measured	6597.56	7240.64	1.09747
	secretory pathway component sec31b-1. [refseq;acc:nm_015490]	Rooted	62.3618	66.0328	1.05887
943	cyclin m4; ancient conserved domain protein 4. [refseq;acc:nm_020184]	Squared	23659.2	27311.3	1.15436
	gamma enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (neural enolase) (nse) (enolase 2). [swissprot;acc:p09104]	Measured	6597.98	7241	1.09746
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Ranked	212.442	205.087	1.03586
	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]	Rooted	62.3617	66.0327	1.05887
944	beta enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (skeletal muscle enolase) (mse) (enolase 3). [swissprot;acc:p13929]	Measured	6597.98	7241	1.09746
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	Ranked	212.437	205.083	1.03586
	tcd37 homolog; prune. [refseq;acc:nm_021222]	Squared	23659.1	27311.1	1.15436
	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	Rooted	62.3614	66.0323	1.05886
945	alpha enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (non- neural enolase) (nne) (enolase 1) (phosphopyruvate hydratase). [swissprot;acc:p06733]	Measured	6597.98	7241	1.09746
	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	Ranked	212.44	205.085	1.03586
	cyclin m1; ancient conserved domain protein 1. [refseq;acc:nm_020348]	Squared	23658.7	27310.2	1.15434
	vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487]	Rooted	62.409	66.0815	1.05885
946	cyclin m3; ancient conserved domain protein 3. [refseq;acc:nm_017623]	Squared	23658.5	27309.8	1.15433
	histone h4. [swissprot;acc:p02304]	Ranked	227.765	219.902	1.03576
	phosphoglycerate kinase 1 (ec 2.7.2.3) (primer recognition protein 2) (prp 2). [swissprot;acc:p00558]	Measured	6598.37	7241.32	1.09744
	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	Rooted	62.4087	66.0813	1.05885
947	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Ranked	212.51	205.191	1.03567
	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]	Rooted	62.4093	66.0819	1.05885
	signal transducing adaptor molecule 1; signal transducing adaptor molecule. [refseq;acc:nm_003473]	Measured	11797.1	10750.2	1.09738
	thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919]	Squared	24999.1	28856.8	1.15431
948	caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	Measured	4633.48	5084.24	1.09728
	target of myb protein 1. [swissprot;acc:o60784]	Ranked	217.254	209.824	1.03541
	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	Rooted	62.4102	66.0829	1.05885
	xylulokinase homolog; xylulokinase (h. influenzae) homolog. [refseq;acc:nm_005108]	Squared	25295.5	29197.3	1.15425
949	apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	Measured	4633.48	5084.24	1.09728
	heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866]	Rooted	82.2821	87.1197	1.05879
	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	Ranked	217.253	209.826	1.0354
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	Squared	27084.5	31257.9	1.15409
950	bystin. [swissprot;acc:q13895]	Measured	4280.99	4697.02	1.09718
	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	Ranked	252.873	261.821	1.03539
	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	Rooted	82.2706	87.1037	1.05875
	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	Squared	16129.2	18614.3	1.15407
951	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	Measured	5364.3	5885.48	1.09716
	gtp cyclohydrolase i (ec 3.5.4.16) (gtp-ch-i). [swissprot;acc:p30793]	Squared	19634.1	22653.4	1.15378
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	Rooted	56.264	59.5672	1.05871
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	Ranked	217.253	209.827	1.03539
952	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	Rooted	56.264	59.5672	1.05871
	my016 protein. [sptrembl;acc:q9h3k6]	Squared	18239.4	21037.9	1.15343
	putative dimethylaniline monooxygenase [n-oxide forming] 6 (ec 1.14.13.8) (flavin-containing monooxygenase 6) (fmo 6) (dimethylaniline oxidase 6). [swissprot;acc:o60774]	Measured	5364.3	5885.48	1.09716

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.