MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Interaction Map	description	Value Type	Network Comparison Type	green	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Interaction Map	description	green	red	network_comparison
251	High confidence	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	166.661	186.172	1.11707
	Low confidence	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	201.035	210.415	1.04666
252	High confidence	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	212.457	237.292	1.11689
	Low confidence	cytochrome b-245 heavy chain (p22 phagocyte b-cytochrome) (neutrophil cytochrome b, 91 kda polypeptide) (cgd91-phox) (gp91-phox) (heme binding membrane glycoprotein gp91phox) (cytochrome b(558) beta chain) (superoxide-generating nadph oxidase heavy chain subunit). [swissprot;acc:p04839]	201.035	210.414	1.04665
253	High confidence	mad protein (max dimerizer). [swissprot;acc:q05195]	204.333	228	1.11583
	Low confidence	nadph oxidase 4. [refseq;acc:nm_016931]	201.035	210.413	1.04665
254	High confidence	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	179.88	200.691	1.11569
	Low confidence	nadph oxidase 3; nadph oxidase catalytic subunit-like 3. [refseq;acc:nm_015718]	201.035	210.414	1.04665
255	High confidence	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	179.88	200.691	1.11569
	Low confidence	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	201.035	210.413	1.04665
256	High confidence	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	204.357	227.999	1.11569
	Low confidence	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	190.521	199.376	1.04648
257	High confidence	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	179.88	200.691	1.11569
	Low confidence	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	192.404	201.316	1.04632
258	High confidence	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	204.366	227.999	1.11564
	Low confidence	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	192.427	201.304	1.04613
259	High confidence	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	204.37	227.999	1.11562
	Low confidence	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	202.482	211.794	1.04599
260	High confidence	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	196.978	219.421	1.11394
	Low confidence	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	207.34	216.855	1.04589
261	High confidence	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	196.978	219.421	1.11394
	Low confidence	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	207.333	216.845	1.04588
262	High confidence	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	196.978	219.421	1.11394
	Low confidence	breast cancer antigen ny-br-1. [refseq;acc:nm_052997]	207.332	216.842	1.04587
263	High confidence	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	196.978	219.421	1.11394
	Low confidence	sodium/hydrogen exchanger 6 (na(+)/h(+) exchanger 6) (nhe-6). [swissprot;acc:q92581]	207.063	216.546	1.0458
264	High confidence	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	196.978	219.421	1.11394
	Low confidence	senescence downregulated leo1-like. [refseq;acc:nm_138792]	207.063	216.546	1.0458
265	High confidence	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	202.459	225.217	1.11241
	Low confidence	solute carrier family 9, member 7; nonselective sodium potassium/proton exchanger; sodium/hydrogen exchanger 7. [refseq;acc:nm_032591]	207.063	216.546	1.0458
266	High confidence	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	267.88	241.07	1.11121
	Low confidence	calcineurin b subunit isoform 1 (protein phosphatase 2b regulatory subunit 1) (protein phosphatase 3 regulatory subunit b alpha isoform 1). [swissprot;acc:p06705]	205.509	214.887	1.04563
267	High confidence	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	267.88	241.07	1.11121
	Low confidence	tensin. [refseq;acc:nm_022648]	205.872	215.258	1.04559
268	High confidence	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	244.167	271.016	1.10996
	Low confidence	sterol o-acyltransferase 2 (ec 2.3.1.26) (cholesterol acyltransferase 2) (acyl coenzyme a:cholesterol acyltransferase 2) (acat-2). [swissprot;acc:o75908]	199.455	208.469	1.04519
269	High confidence	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	267.352	241.373	1.10763
	Low confidence	sterol o-acyltransferase 1 (ec 2.3.1.26) (cholesterol acyltransferase 1) (acyl coenzyme a:cholesterol acyltransferase 1) (acat-1). [swissprot;acc:p35610]	199.44	208.436	1.04511
270	High confidence	fad synthetase. [refseq;acc:nm_025207]	267.352	241.373	1.10763
	Low confidence	ring finger protein 10. [refseq;acc:nm_014868]	199.44	208.437	1.04511
271	High confidence	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	267.352	241.373	1.10763
	Low confidence	tropomyosin alpha 4 chain (tropomyosin 4) (tm30p1). [swissprot;acc:p07226]	192.595	201.219	1.04478
272	High confidence	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	267.352	241.373	1.10763
	Low confidence	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	208.421	217.69	1.04447
273	High confidence	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	267.352	241.373	1.10763
	Low confidence	parafibromin. [refseq;acc:nm_024529]	204.916	214.015	1.0444
274	High confidence	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	267.352	241.373	1.10763
	Low confidence	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	200.653	209.532	1.04425
275	High confidence	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	267.352	241.373	1.10763
	Low confidence	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	191.203	199.66	1.04423

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.