MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 350 to 399 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	red	green	network_comparison
175	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	1	4456.67	5773.77	1.29553
176	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]		4456.93	5773.67	1.29544
	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	0	3023.85	2436.4	1.24111
177	acrc protein; putative nuclear protein. [refseq;acc:nm_052957]		4131.06	3340.03	1.23683
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	1	4457.06	5773.63	1.29539
178	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]	0	498.07	615.233	1.23523
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	1	21591.5	27904.5	1.29238
179	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	0	556	681	1.22482
	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	1	21591.5	27904.5	1.29238
180	dc11 protein. [refseq;acc:nm_020186]	0	556	681	1.22482
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	1	21591.5	27904.5	1.29238
181	enigma protein; lim domain protein. [refseq;acc:nm_005451]	0	187.25	153	1.22386
	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	1	4068.56	5252.6	1.29102
182	rna-binding protein. [refseq;acc:nm_019027]		4069.83	5252.17	1.29051
	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	0	971.889	794.63	1.22307
183	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	1	4069.83	5252.17	1.29051
	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	0	375.07	306.727	1.22281
184	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
	ns1-associated protein 1. [refseq;acc:nm_006372]	1	4069.83	5252.17	1.29051
185	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	0	375.322	306.933	1.22281
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	1	4069.83	5252.17	1.29051
186	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]		4071.1	5251.75	1.29001
	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]	0	470.251	384.733	1.22228
187	importin 9. [refseq;acc:nm_018085]		1143.55	1397.66	1.22221
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	1	4569.48	5885.79	1.28807
188	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	0	1143.55	1397.66	1.22221
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	1	4571.89	5864.86	1.28281
189	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]
	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	0	1249.24	1023.76	1.22025
190	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	1	4571.89	5864.86	1.28281
	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	0	14	11.5	1.21739
191	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		743.066	904.149	1.21678
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	1	4638.1	5923.4	1.27712
192	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]		17757.5	14008	1.26767
	sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4]	0	1965.47	2389.69	1.21584
193	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		23818.1	19621.3	1.21389
	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	1	17756.5	14007.3	1.26766
194	cyclin g2. [swissprot;acc:q16589]		17738.6	13995.7	1.26743
	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]	0	125.5	103.5	1.21256
195	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		23	19	1.21053
	cyclin g1 (cyclin g). [swissprot;acc:p51959]	1	17738.5	13995.6	1.26743
196	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]			13995.7	1.26742
	t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]	0	465.37	562.085	1.20782
197	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]		2145.97	1784.22	1.20275
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	1	17738.5	13995.7	1.26742
198	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]		17710.9	13977.7	1.26708
	secreted modular calcium-binding protein 1. [refseq;acc:nm_022137]	0	247.333	206	1.20065
199	glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104]		1230.54	1026.18	1.19915
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	1	4916.8	3888.18	1.26455
200	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]		4808.79	6074.21	1.26315

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.