MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 5286 to 5335 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
1322	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	Ranked	159.86	156.275	1.02294
	histone h2b.s (h2b/s). [swissprot;acc:p57053]	Squared	15254.5	17204.9	1.12786
	scratch; scratch 1. [refseq;acc:nm_031309]	Rooted	67.9472	70.8115	1.04215
1323	cytoplasmic protein nck2 (nck adaptor protein 2) (sh2/sh3 adaptor protein nck-beta) (nck-2). [swissprot;acc:o43639]	Ranked	205.225	200.625	1.02293
	dj850e9.1 (novel c2h2 type zinc finger protein similar to drosophila scratch (scrt), slug and xenopus snail) (fragment). [sptrembl;acc:q9nq03]	Rooted	67.9155	70.7734	1.04208
	glycogen synthase kinase-3 alpha (ec 2.7.1.37) (gsk-3 alpha). [swissprot;acc:p49840]	Measured	6439.79	6959.21	1.08066
	histone h2b.d (h2b/d). [swissprot;acc:q99877]	Squared	15254.5	17204.9	1.12786
1324	glycogen synthase kinase-3 beta (ec 2.7.1.37) (gsk-3 beta). [swissprot;acc:p49841]	Measured	6439.79	6959.21	1.08066
	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	Ranked	159.993	156.421	1.02284
	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Squared	15254.5	17204.9	1.12786
	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	Rooted	68.9332	71.8139	1.04179
1325	importin beta-1 subunit (karyopherin beta-1 subunit) (nuclear factor p97) (importin 90). [swissprot;acc:q14974]
	serine/threonine protein phosphatase 2b catalytic subunit, alpha isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, alpha isoform) (cam-prp catalytic subunit). [swissprot;acc:q08209]	Measured	5656.79	6112.02	1.08047
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	Squared	15254.5	17204.9	1.12786
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	Ranked	217.133	212.289	1.02282
1326	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]		218.509	213.648	1.02275
	histone h2b.e (h2b/e). [swissprot;acc:q99879]	Squared	15254.5	17204.9	1.12786
	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Measured	6222.8	6723.54	1.08047
	transducin beta-like 1x protein (transducin-beta-like 1, x-linked). [swissprot;acc:o60907]	Rooted	68.9332	71.8139	1.04179
1327	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	Squared	32117.3	36220.6	1.12776
	p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671]	Measured	5656.8	6111.9	1.08045
	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	Rooted	68.9332	71.8139	1.04179
	zinc finger protein zic 4 (zinc finger protein of the cerebellum 4) (fragment). [swissprot;acc:q8n9l1]	Ranked	218.509	213.648	1.02275
1328	autoantigen ngp-1. [swissprot;acc:q13823]	Squared	14345.8	16176.5	1.12761
	calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206]	Ranked	218.509	213.649	1.02275
	leucyl-trna synthetase. [refseq;acc:nm_020117]	Rooted	60.8452	63.3735	1.04155
	serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299]	Measured	5656.81	6111.84	1.08044
1329	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]	Ranked	218.509	213.648	1.02275
	probable leucyl-trna synthetase, mitochondrial precursor (ec 6.1.1.4) (leucine--trna ligase) (leurs). [swissprot;acc:q15031]	Rooted	60.8453	63.3735	1.04155
	serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454]	Measured	5656.82	6111.8	1.08043
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	Squared	14429.1	16268.2	1.12746
1330	calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]	Ranked	218.508	213.648	1.02275
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	Measured	5779.83	6244.56	1.08041
	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Squared	15612.5	17598.4	1.1272
	serine/threonine protein phosphatase 4 (ec 3.1.3.16) (pp4) (protein phosphatase x) (pp-x). [swissprot;acc:p33172]	Rooted	59.8171	62.2984	1.04148
1331	calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	Ranked	218.509	213.649	1.02275
	immunoglobulin-binding protein 1 (cd79a-binding protein 1) (b cell signal transduction molecule alpha 4) (alpha 4 protein). [swissprot;acc:p78318]	Rooted	59.8171	62.2984	1.04148
	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Squared	22156.3	24969.2	1.12696
	transaldolase (ec 2.2.1.2). [swissprot;acc:p37837]	Measured	5799.29	6265.2	1.08034
1332	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]	Ranked	220.681	215.78	1.02271
	my016 protein. [sptrembl;acc:q9h3k6]	Measured	4775.25	5158.86	1.08033
	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	Squared	22156.3	24969.2	1.12696
	ubiquitin-conjugating enzyme e2 n (ec 6.3.2.19) (ubiquitin-protein ligase n) (ubiquitin carrier protein n) (ubc13) (bendless-like ubiquitin conjugating enzyme). [swissprot;acc:q16781]	Rooted	64.3618	67.0301	1.04146
1333	60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]	Ranked	220.681	215.78	1.02271
	abl-interactor 2; abl-interacting protein 1 (sh3-containing protein); abl binding protein 3; arg protein tyrosine kinase-binding protein; abl-interactor protein 2b; similar to spectrin sh3 domain binding protein 1. [refseq;acc:nm_005759]	Measured	5803.95	6269.44	1.0802
	maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368]	Rooted	64.4276	67.0936	1.04138
	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	Squared	22156.3	24969.2	1.12696
1334	15 kda selenoprotein precursor. [swissprot;acc:o60613]	Rooted	64.5959	67.2624	1.04128
	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	Squared	15967.6	17992.4	1.12681
	jm4 protein. [refseq;acc:nm_007213]	Ranked	199.643	204.163	1.02264

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.