MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Value Type	Interaction Map	green	red	network_comparison
63	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Squared	High confidence	129762	219048	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Measured		2765.82	4489.19	1.6231
	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Ranked	Low confidence	239.902	265.688	1.10749
	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	Rooted		68.1264	61.4851	1.10801
64	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		High confidence	47.2654	63.8686	1.35128
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Measured		2765.82	4489.19	1.6231
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Ranked		336.159	266.868	1.25965
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Squared		129762	219048	1.68808
	neurochondrin. [refseq;acc:nm_014284]		Low confidence	57498.7	73677.6	1.28138
	rab11-family interacting protein 4. [refseq;acc:nm_032932]	Rooted		81.4944	73.6221	1.10693
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Measured		17572.7	15464.1	1.13635
	transcription factor jun-d. [swissprot;acc:p17535]	Ranked		183.361	202.709	1.10552
65	eferin. [swissprot;acc:o75154]	Rooted		81.4944	73.6221	1.10693
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]		High confidence	47.2654	63.8686	1.35128
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Ranked		336.077	267.136	1.25807
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Squared		129762	219048	1.68808
	neuralized-like. [refseq;acc:nm_004210]	Measured		2690.25	1657.68	1.6229
	septin 6. [swissprot;acc:q14141]		Low confidence	14773.7	13005.8	1.13593
	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Squared		95493.3	75490.8	1.26497
	transcription factor jun-b. [swissprot;acc:p17275]	Ranked		183.388	202.728	1.10546
66	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Rooted		61.8016	55.8923	1.10573
	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]		High confidence	47.2654	63.8686	1.35128
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Ranked		336.077	267.136	1.25807
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Squared		129762	219048	1.68808
	mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749]	Ranked	Low confidence	200.783	221.902	1.10518
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Measured	High confidence	3221.38	1991.03	1.61795
	septin 10 isoform 1. [refseq;acc:nm_144710]	Squared	Low confidence	94281	74803.9	1.26038
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Measured		5555.81	4900.7	1.13368
67	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		High confidence	10307.5	6475.5	1.59177
	brachyury protein (t protein). [swissprot;acc:o15178]	Rooted	Low confidence	68.2003	61.687	1.10559
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Ranked	High confidence	336.075	267.14	1.25805
	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Measured	Low confidence	13781.8	12176.9	1.1318
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Squared	High confidence	129762	219048	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Rooted		47.2654	63.8686	1.35128
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Ranked	Low confidence	149.799	165.535	1.10505
	septin 6. [swissprot;acc:q14141]	Squared		93531.9	74378.4	1.25751
68	60s ribosomal protein l37a. [swissprot;acc:p12751]	Ranked		217.005	239.692	1.10455
	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Measured	High confidence	10307.5	6475.5	1.59177
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Rooted		47.2654	63.8686	1.35128
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Ranked		336.075	267.139	1.25805
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Squared		129762	219048	1.68808
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Measured	Low confidence	17265.4	19498.1	1.12932
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Rooted		61.8641	55.9786	1.10514
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Squared		35068.7	27909.1	1.25653
69	amino acid transporter xat2; likely ortholog of mouse aspartate/glutamate transporter 1 (agt1). [refseq;acc:nm_138817]	Measured		7848.45	6991.78	1.12253
	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Rooted		67.1136	60.7884	1.10405
	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor (ec 1.5.1.12) (p5c dehydrogenase). [swissprot;acc:p30038]	Squared		64191.7	80538.1	1.25465
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Ranked	High confidence	336.075	267.14	1.25805
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Squared		129762	219048	1.68808
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	Rooted		37.2872	27.9136	1.33581

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.