MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Filtered	Value Type	Network Comparison Type	Interaction Map	red	network_comparison	green

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Showing element 551 to 600 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Filtered	red	network_comparison	green
cab2. [refseq;acc:nm_033419]	2	0	0.00001	17400000	174
	2618	1	5599.85	1.01485	5683
cad protein [includes: glutamine-dependent carbamoyl-phosphate synthase (ec 6.3.5.5); aspartate carbamoyltransferase (ec 2.1.3.2); dihydroorotase (ec 3.5.2.3)]. [swissprot;acc:p27708]	1217		6021.21	1.08557	6536.45
cadherin-related tumor suppressor homolog precursor (fat protein homolog). [swissprot;acc:q14517]	1723		5458.12	1.06827	5830.76
calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]	1356		5657.71	1.07881	6103.57
calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206]	1360		5657.72	1.07879	6103.52
calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	1361
calcium-binding mitochondrial carrier protein aralar1 (solute carrier family 25, member 12). [swissprot;acc:o75746]	1913		6858.84	1.06246	7287.27
calcium-binding mitochondrial carrier protein aralar2 (solute carrier family 25, member 13) (citrin). [swissprot;acc:q9ujs0]	1916
calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	440		6251.91	1.15038	7192.08
calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	606		6148.94	1.13121	6955.76
calcium/calmodulin-dependent protein kinase type ii alpha chain (ec 2.7.1.123) (cam-kinase ii alpha chain) (cam kinase ii alpha subunit) (camk-ii alpha subunit). [swissprot;acc:q9uqm7]	1385		6079.45	1.07829	6555.4
calcium/calmodulin-dependent protein kinase type ii beta chain (ec 2.7.1.123) (cam-kinase ii beta chain) (cam kinase ii beta subunit) (camk-ii beta subunit). [swissprot;acc:q13554]	1386		6079.46		6555.41
calcium/calmodulin-dependent protein kinase type ii delta chain (ec 2.7.1.123) (cam-kinase ii delta chain) (cam kinase ii delta subunit) (camk-ii delta subunit). [swissprot;acc:q13557]	1376
calcium/calmodulin-dependent protein kinase type ii gamma chain (ec 2.7.1.123) (cam-kinase ii gamma chain) (cam kinase ii gamma subunit) (camk-ii gamma subunit) (fragment). [swissprot;acc:q13555]	1375		6079.45		6555.4
calcyphosine. [swissprot;acc:q13938]	126	0	472.524	1.3457	635.875
	365	1	5189	1.17334	6088.47
calmegin precursor. [swissprot;acc:o14967]	1473		5910.06	1.0753	6355.08
calmodulin. [swissprot;acc:p02593]	2928		0.00001	1	0.00001
calnexin precursor (major histocompatibility complex class i antigen-binding protein p88) (p90) (ip90). [swissprot;acc:p27824]	1474		5910.06	1.0753	6355.08
calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	2384		4164.96	1.04129	4336.92
calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	2383		4164.76	1.04136	4337.01
calreticulin precursor (crp55) (calregulin) (hacbp) (erp60). [swissprot;acc:p27797]	1526		5369.1	1.0735	5763.72
calsyntenin-1 precursor. [swissprot;acc:o94985]	536		10603.5	1.13826	12069.5
calsyntenin-2 precursor. [swissprot;acc:q9h4d0]	541		10600.3	1.13819	12065.2
calsyntenin-3 precursor. [swissprot;acc:q9bqt9]	543		10599.9		12064.7
camp response element-binding protein cre-bpa. [refseq;acc:nm_004904]	1439		5658.8	1.07683	6093.56
camp responsive element binding protein-like 2. [refseq;acc:nm_001310]	3078		0.00001	1	0.00001
camp-dependent protein kinase type i-alpha regulatory chain (tissue- specific extinguisher-1) (tse1). [swissprot;acc:p10644]	3089
camp-dependent protein kinase type ii-alpha regulatory chain. [swissprot;acc:p13861]	1710		5916.13	1.06857	6321.77
camp-dependent protein kinase type ii-beta regulatory chain. [swissprot;acc:p31323]	1715		5918.48	1.06849	6323.83
camp-dependent protein kinase, alpha-catalytic subunit (ec 2.7.1.37) (pka c-alpha). [swissprot;acc:p17612]	1714		5917.23	1.06853	6322.73
camp-dependent protein kinase, beta-catalytic subunit (ec 2.7.1.37) (pka c-beta). [swissprot;acc:p22694]	1713
camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612]	381	0	2509.05	1.04972	2633.79
	1712	1	5917.23	1.06853	6322.73
candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	2025		4813.13	1.05781	5091.36
carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	2351		8353.97	1.04406	8001.45
carboxypeptidase a5. [refseq;acc:nm_080385]	2344
carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	2345
carboxypeptidase b precursor. [refseq;acc:nm_020361]	239		7711.38	1.23071	6265.8
carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	316	0	525	1.09714	576
	719	1	6593.17	1.117	7364.55
carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]	717
carcinoma related gene. [refseq;acc:nm_016041]	3179		0.00001	1	0.00001
carnitine o-acetyltransferase (ec 2.3.1.7) (carnitine acetylase) (cat). [swissprot;acc:p43155]	1093		5791.05	1.09075	6316.61
carnitine o-palmitoyltransferase ii, mitochondrial precursor (ec 2.3.1.21) (cpt ii). [swissprot;acc:p23786]	2885		0.00001	1	0.00001
cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	207	0	403.827	1.19069	339.154
	2220	1	3936.2	1.04816	3755.33
casein kinase i alpha s-like. [refseq;acc:nm_145203]	238	0	2198.47	1.13678	1933.94
	953	1	4906.33	1.09705	5382.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.