MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2875 to 2924 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1438	geranylgeranyl transferase type i beta subunit (ec 2.5.1.-) (type i protein geranyl-geranyltransferase beta subunit) (ggtase-i-beta). [swissprot;acc:p53609]	Divided	225.039	229.573	1.02015
	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Subtracted	166.846	170.989	4.143
1439	fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [refseq;acc:nm_021727]	Divided	225.039	229.573	1.02015
	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Subtracted	166.846	170.989	4.143
1440	mothers against decapentaplegic homolog 4 (smad 4) (mothers against dpp homolog 4) (deletion target in pancreatic carcinoma 4) (hsmad4). [swissprot;acc:q13485]	Divided	225.039	229.573	1.02015
	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	Subtracted	224.159	220.017	4.142
1441	fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [refseq;acc:nm_004265]	Divided	225.039	229.573	1.02015
	glucose-6-phosphate isomerase (ec 5.3.1.9) (gpi) (phosphoglucose isomerase) (pgi) (phosphohexose isomerase) (phi) (neuroleukin) (nlk) (sperm antigen-36) (sa-36). [swissprot;acc:p06744]	Subtracted	217.704	221.839	4.135
1442	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	Divided	225.039	229.573	1.02015
	ran-gtp binding protein (fragment). [sptrembl;acc:o60518]	Subtracted	218.591	214.457	4.134
1443	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]	Divided	203.908	207.998	1.02006
	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	Subtracted	172.543	168.417	4.126
1444	cleavage and polyadenylation specific factor 6, 68 kd subunit; pre-mrna cleavage factor im (68kd); cleavage and polyadenylation specific factor 6, 68kd subunit; pre-mrna cleavage factor i, 68kd subunit. [refseq;acc:nm_007007]		218.664	214.55	4.114
	glutamate dehydrogenase 1, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p00367]	Divided	203.908	207.998	1.02006
1445	exportin 1; exportin-1 (required for chromosome region maintenance); exportin 1 (crm1, yeast, homolog); crm1, yeast, homolog. [refseq;acc:nm_003400]	Subtracted	224.476	220.363	4.113
	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	Divided	134.233	136.922	1.02003
1446	heat shock 27 kda protein (hsp 27) (stress-responsive protein 27) (srp27) (estrogen-regulated 24 kda protein) (28 kda heat shock protein). [swissprot;acc:p04792]		221.817	226.23	1.01989
	neurotrimin precursor (hnt). [swissprot;acc:q9p121]	Subtracted	224.022	219.924	4.098
1447	dna polymerase epsilon p17 subunit (dna polymerase epsilon subunit 3) (chromatin accessibility complex 17) (huchrac17) (chrac-17). [swissprot;acc:q9nrf9]	Divided	250.854	255.842	1.01988
	transcription factor smif; decapping enzyme hdcp1a. [refseq;acc:nm_018403]	Subtracted	224.509	220.411	4.098
1448	caax prenyl protease 1 homolog (ec 3.4.24.-) (prenyl protein-specific endoprotease 1) (farnesylated-proteins converting enzyme 1) (face-1) (zinc metalloproteinase ste24 homolog). [swissprot;acc:o75844]	Divided	226.532	222.117	1.01988
	reticulon 4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5) (my043 protein). [swissprot;acc:q9nqc3]	Subtracted	207.038	211.13	4.092
1449	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p49448]		203.908	207.998	4.09
	transportin-sr; importin 12. [refseq;acc:nm_012470]	Divided	225.305	229.766	1.0198
1450	alpha crystallin c chain (small stress protein-like protein hsp22) (e2ig1) (protein kinase h11). [swissprot;acc:q9ujy1]		221.804	226.194	1.01979
	glutamate dehydrogenase 1, mitochondrial precursor (ec 1.4.1.3) (gdh). [swissprot;acc:p00367]	Subtracted	203.908	207.998	4.09
1451	my016 protein. [sptrembl;acc:q9h3k6]	Divided	224.755	229.2	1.01978
	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	Subtracted	207.024	211.089	4.065
1452	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	Divided	160.381	163.554	1.01978
	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	Subtracted	212.001	207.937	4.064
1453	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]		207.024	211.086	4.062
	reticulon 4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5) (my043 protein). [swissprot;acc:q9nqc3]	Divided	207.038	211.13	1.01976
1454	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Subtracted	240.077	236.015	4.062
	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	Divided	207.024	211.089	1.01964
1455	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]			211.085	1.01962
	eh-domain containing protein 2. [swissprot;acc:q9nzn4]	Subtracted		211.086	4.062
1456	eh-domain containing protein 3. [swissprot;acc:q9nzn3]
	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	Divided			1.01962
1457	eh-domain containing protein 2. [swissprot;acc:q9nzn4]
	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]	Subtracted	215.328	211.267	4.061
1458	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]		207.024	211.085
	eh-domain containing protein 3. [swissprot;acc:q9nzn3]	Divided		211.086	1.01962
1459	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]		192.336	188.637	1.01961
	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	Subtracted	207.019	211.077	4.058
1460	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]		215.122	211.066	4.056
	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	Divided	205.817	209.851	1.0196
1461	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	Subtracted	171.231	167.177	4.054
	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	Divided	207.019	211.077	1.0196
1462	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]		205.817	209.851
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	Subtracted	171.231	167.177	4.054

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.