MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1477 to 1526 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
739	cellular modulator of immune recognition. [refseq;acc:nm_145021]	Divided	5768.32	6434.78	1.11554
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Subtracted	5248.07	5901.72	653.65
740	syntaxin 7. [swissprot;acc:o15400]		5580.97	6233.52	652.55
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	Divided	5768.32	6434.78	1.11554
741	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]
	sipl protein. [refseq;acc:nm_018269]	Subtracted	6522.94	7175.18	652.24
742	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]		4864.66	5514.87	650.21
	eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]	Divided	4131.04	4607.9	1.11543
743	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	Subtracted	4864.66	5514.87	650.21
	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	Divided	4131.04	4607.9	1.11543
744	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	Subtracted	9903.22	9253.79	649.43
	cytidine triphosphate synthase ii; ctp synthetase type 2; utp-ammonia ligase; ctp synthetase isoform; cytidine 5'-triphosphate synthetase 2. [refseq;acc:nm_019857]	Divided	12515.4	11221.1	1.11535
745	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	Subtracted	9899.79	9251.2	648.59
	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	Divided	4086.6	4557.68	1.11527
746	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	Subtracted	9899.73	9251.16	648.57
	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	Divided	4086.6	4557.68	1.11527
747	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	Subtracted	9899.73	9251.16	648.57
	down-regulated in metastasis. [refseq;acc:nm_014503]	Divided	4086.6	4557.68	1.11527
748	ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812]		12503.3	11212	1.11517
	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	Subtracted	9899.73	9251.16	648.57
749	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]		3432.96	4081.21	648.25
	ethanolamine-phosphate cytidylyltransferase (ec 2.7.7.14) (phosphorylethanolamine transferase) (ctp:phosphoethanolamine cytidylyltransferase). [swissprot;acc:q99447]	Divided	4565.34	5085.92	1.11403
750	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	Subtracted	9895.77	9248.18	647.59
	myosin light chain 1, skeletal muscle isoform (mlc1f) (a1 catalytic) (alkali). [swissprot;acc:p05976]	Divided	4565.34	5085.92	1.11403
751	cathepsin b precursor (ec 3.4.22.1) (cathepsin b1) (app secretase). [swissprot;acc:p07858]	Subtracted	6513.45	7161	647.55
	myosin light chain 1, slow-twitch muscle b/ventricular isoform (mlc1sb) (alkali). [swissprot;acc:p08590]	Divided	4565.34	5085.92	1.11403
752	cerebral cell adhesion molecule. [refseq;acc:nm_016174]	Subtracted	9596.59	10241.9	645.31
	nadh-ubiquinone oxidoreductase 13 kda-a subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-a) (ci-13kd-a). [swissprot;acc:o75380]	Divided	4565.34	5085.92	1.11403
753	dna damage binding protein 1 (damage-specific dna binding protein 1) (ddb p127 subunit) (ddba) (uv-damaged dna-binding protein 1) (uv-ddb 1) (xeroderma pigmentosum group e complementing protein) (xpce) (x- associated protein 1) (xap-1). [swissprot;acc:q16531]	Subtracted	6194.15	6839.37	645.22
	myosin light chain 1, slow-twitch muscle a isoform (mlc1sa) (alkali). [swissprot;acc:p14649]	Divided	4565.34	5085.92	1.11403
754	myosin light chain 1, embryonic muscle/atrial isoform (pro1957). [swissprot;acc:p12829]
	propionyl-coa carboxylase beta chain, mitochondrial precursor (ec 6.4.1.3) (pccase beta subunit) (propanoyl-coa:carbon dioxide ligase beta subunit). [swissprot;acc:p05166]	Subtracted	6194.15	6839.37	645.22
755	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Divided	4079.81	4545.01	1.11402
	transcription initiation factor iib (general transcription factor tfiib) (s300-ii). [swissprot;acc:q00403]	Subtracted	4651.88	5296.78	644.9
756	thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649]
	topoisomerase-related function protein 4-2. [refseq;acc:nm_022447]	Divided	4725.28	5261.06	1.11339
757	nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]	Subtracted	4651.88	5296.78	644.9
	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Divided	5622.89	6260.02	1.11331
758	dna polymerase epsilon subunit b (ec 2.7.7.7) (dna polymerase ii subunit b). [swissprot;acc:p56282]		3760.3	4185.82	1.11316
	nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]	Subtracted	4651.88	5296.78	644.9
759	6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813]	Divided	4254.62	4736.03	1.11315
	phosphoglycerate kinase, testis specific (ec 2.7.2.3). [swissprot;acc:p07205]	Subtracted	6597.56	7240.64	643.08
760	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]	Divided	5870.2	6533.39	1.11298
	gamma enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (neural enolase) (nse) (enolase 2). [swissprot;acc:p09104]	Subtracted	6597.98	7241	643.02
761	beta enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (skeletal muscle enolase) (mse) (enolase 3). [swissprot;acc:p13929]
	translation initiation factor if-2. [swissprot;acc:o60841]	Divided	5811.51	6467.62	1.1129
762	alpha enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (non- neural enolase) (nne) (enolase 1) (phosphopyruvate hydratase). [swissprot;acc:p06733]	Subtracted	6597.98	7241	643.02
	pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	Divided	6231.31	6933.9	1.11275
763	6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]		4250.54	4729.67	1.11272
	phosphoglycerate kinase 1 (ec 2.7.2.3) (primer recognition protein 2) (prp 2). [swissprot;acc:p00558]	Subtracted	6598.37	7241.32	642.95

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.