MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 9634 in total

Value Type  : Ranked
Network Comparison Type  : Divided

Rank	Hugo	description	Filtered	Interaction Map	red	green	network_comparison
1	ARFGAP3	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	0	High confidence	4294	15915	3.70633
	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	1	Low confidence	16	32	2
	STARD3	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	0		5865	14977	2.55362
	UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	1	High confidence	10	24	2.4
2	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]			15	28	1.86667
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	Low confidence	8906	21883	2.45711
	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	1		223	330	1.47982
	STARD3	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	0	High confidence	5865	14977	2.55362
3	no value	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]			4475.84	11083.9	2.47638
	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	1	Low confidence	223	330	1.47982
	NOTCH1	neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]	0		9607	20617	2.14604
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	1	High confidence	15	28	1.86667
4	no value	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0		8906	21883	2.45711
	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	1	Low confidence	223	330	1.47982
	NOTCH2	neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]	0		9607	20617	2.14604
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	1	High confidence	15	28	1.86667
5	no value	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	0		5510.5	11965.7	2.17144
	LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	1	Low confidence	223	330	1.47982
	PSCD4	cytohesin 4. [swissprot;acc:q9uia0]		High confidence	15	28	1.86667
	UTY	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]	0	Low confidence	10889.4	19873	1.82499
6	no value	trinucleotide repeat containing 15. [refseq;acc:nm_015575]			5575.71	9583.37	1.71877
	OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	1		318	240	1.325
	PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		High confidence	15	28	1.86667
	UBE3B	ubiquitin protein ligase. [refseq;acc:nm_130466]	0		7523	15339.2	2.03897
7	no value	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]		Low confidence	11543	6812	1.69451
	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	1	High confidence	215	322	1.49767
	OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		Low confidence	318	240	1.325
	PERLD1	cab2. [refseq;acc:nm_033419]	0	High confidence	21866	10950	1.99689
8	no value	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		Low confidence	22286	13216	1.68629
		nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]		High confidence	11525	21888	1.89918
	HBS1L	hbs1-like. [refseq;acc:nm_006620]	1		215	322	1.49767
	OSBPL7	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]		Low confidence	318	240	1.325
9	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	0		22286	13216	1.68629
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	1		58	44	1.31818
	TBL1Y	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	0	High confidence	11525	21888	1.89918
	XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	1		212	309	1.45755
10	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0	Low confidence	22286	13216	1.68629
	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]	1	High confidence	212	309	1.45755
	FBP2	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	0		7509.39	14178.1	1.88805
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	1	Low confidence	58	44	1.31818
11	no value	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	0		13730.5	8257	1.66289
	ATP9A	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]		High confidence	11627	6248	1.86092
	BEST1	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	1	Low confidence	37.318	28.4944	1.30966
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]		High confidence	337	232	1.45259
12	no value	anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	0	Low confidence	3190	1933	1.65028
	BEST4	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	1		37.3475	28.5242	1.30933
	FPGS	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	0	High confidence	9429.18	5208.84	1.81023
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1		337	232	1.45259
13	no value	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	0		5210.5	9264.5	1.77804
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	1	Low confidence	37.9984	29.1831	1.30207

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.