MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1208 to 1257 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
604	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Subtracted	194.371	207.272	12.901
605	histone h2b.c (h2b/c). [swissprot;acc:q99880]	Divided	233.441	247.47	1.0601
	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted	212.945	225.829	12.884
606	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Divided	233.441	247.47	1.0601
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Subtracted	194.452	207.309	12.857
607	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Divided	233.441	247.47	1.0601
	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	Subtracted	229.549	216.731	12.818
608	dynein light chain 2. [refseq;acc:nm_080677]
	histone h2b. [refseq;acc:nm_175055]	Divided	233.441	247.47	1.0601
609	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	Subtracted	213.786	226.523	12.737
	histone h2b.s (h2b/s). [swissprot;acc:p57053]	Divided	233.441	247.47	1.0601
610	histone h2b.d (h2b/d). [swissprot;acc:q99877]
	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Subtracted	193.021	205.74	12.719
611	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Divided	233.441	247.47	1.0601
	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	Subtracted	216.276	228.986	12.71
612	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]		193.183	205.89	12.707
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	Divided	233.441	247.47	1.0601
613	histone h2b.e (h2b/e). [swissprot;acc:q99879]
	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Subtracted	235.074	247.769	12.695
614	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Divided	202.125	214.257	1.06002
	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	Subtracted	245.048	232.468	12.58
615	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]		229.35	241.907	12.557
	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Divided	202.132	214.257	1.05999
616	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]
	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	Subtracted	190.24	177.698	12.542
617	carboxypeptidase b precursor. [refseq;acc:nm_020361]		190.239		12.541
	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Divided	202.135	214.257	1.05997
618	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]		202.139	214.256	1.05994
	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Subtracted	190.24	177.699	12.541
619	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	Divided	202.139	214.256	1.05994
	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Subtracted	218.792	206.274	12.518
620	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	Divided	202.14	214.256	1.05994
	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Subtracted	218.792	206.274	12.518
621	60s acidic ribosomal protein p2. [swissprot;acc:p05387]		244.435	231.92	12.515
	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Divided	202.14	214.256	1.05994
622	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]
	synapsin iii. [swissprot;acc:o14994]	Subtracted	216.576	229.072	12.496
623	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Divided	202.14	214.256	1.05994
624	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Subtracted	216.576	229.072	12.496
	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	Divided	202.139	214.256	1.05994
625	actin binding lim protein 2. [refseq;acc:nm_032432]	Subtracted	216.576	229.072	12.496
	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	Divided	202.14	214.256	1.05994
626	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]
	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Subtracted	216.576	229.072	12.496
627	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Divided	202.139	214.256	1.05994
	synapsin ii. [swissprot;acc:q92777]	Subtracted	216.576	229.072	12.496
628	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Divided	202.14	214.256	1.05994
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Subtracted	216.576	229.072	12.496
629	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Divided	202.14	214.256	1.05994

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.