MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 632 to 681 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
158	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Squared	89182.8	125229	1.40418
159	necdin. [swissprot;acc:q99608]	Measured	23693.7	18263	1.29736
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Ranked	249.663	298.263	1.19466
	rna-binding protein. [refseq;acc:nm_019027]	Rooted	52.7642	61.9019	1.17318
	septin 6. [swissprot;acc:q14141]	Squared	88953.6	124854	1.40359
160	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Rooted	52.7642	61.9019	1.17318
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Ranked	249.663	298.263	1.19466
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Squared	173408	242989	1.40126
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Measured	23693.7	18263	1.29736
161	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Squared	173408	242989	1.40126
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Measured	23693.7	18263	1.29736
	ns1-associated protein 1. [refseq;acc:nm_006372]	Rooted	52.7642	61.9019	1.17318
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Ranked	249.663	298.263	1.19466
162	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Rooted	52.7642	61.9019	1.17318
	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Squared	173408	242989	1.40126
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Measured	23693.7	18263	1.29736
	nostrin. [refseq;acc:nm_052946]	Ranked	209.299	249.187	1.19058
163	eap30 subunit of ell complex. [refseq;acc:nm_007241]
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Rooted	52.7702	61.8915	1.17285
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Squared	173408	242989	1.40126
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Measured	23693.7	18263	1.29736
164	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Squared	173408	242989	1.40126
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	Ranked	209.299	249.187	1.19058
	mad protein (max dimerizer). [swissprot;acc:q05195]	Rooted	55.646	65.1534	1.17086
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Measured	23693.7	18263	1.29736
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	Ranked	209.299	249.187	1.19058
	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Squared	173408	242989	1.40126
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	Rooted	55.6486	65.1478	1.1707
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Measured	23693.7	18263	1.29736
166	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	Ranked	209.299	249.187	1.19058
	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Squared	173408	242989	1.40126
	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Rooted	55.6495	65.1458	1.17064
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Measured	23693.7	18263	1.29736
167	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	Ranked	209.299	249.187	1.19058
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Squared	173408	242989	1.40126
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Rooted	55.65	65.1448	1.17062
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Measured	23693.7	18263	1.29736
168	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Ranked	82.5916	98.0548	1.18722
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Measured	23693.7	18263	1.29736
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Squared	173408	242989	1.40126
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Rooted	56.3709	65.8949	1.16895
169	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Ranked	82.5916	98.0548	1.18722
	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	Rooted	62.762	53.7761	1.1671
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Measured	23693.7	18263	1.29736
	symplekin. [swissprot;acc:q92797]	Squared	124118	88668.8	1.39979
170	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	Rooted	53.4993	45.9227	1.16499
	cytidine triphosphate synthase ii; ctp synthetase type 2; utp-ammonia ligase; ctp synthetase isoform; cytidine 5'-triphosphate synthetase 2. [refseq;acc:nm_019857]	Squared	96730.5	69286.7	1.39609
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Measured	23693.7	18263	1.29736
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Ranked	227.199	192.715	1.17894
171	ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812]	Squared	96602.7	69211.2	1.39577

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.