MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2525 to 2574 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
632	actin binding lim protein 2. [refseq;acc:nm_032432]	Rooted	60.0129	64.7371	1.07872
	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Measured	6228.39	7013.19	1.126
	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Ranked	214.254	202.166	1.05979
	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Squared	32192.5	37966.8	1.17937
633	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	Ranked	234.106	248.104	1.05979
	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Measured	6228.39	7013.19	1.126
	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Squared	32192.8	37967.2	1.17937
	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Rooted	60.0129	64.7371	1.07872
634	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	Ranked	226.523	213.786	1.05958
	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Measured	6228.39	7013.19	1.126
	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Squared	32192.8	37967.1	1.17937
	synapsin ii. [swissprot;acc:q92777]	Rooted	60.0129	64.7371	1.07872
635	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	Ranked	228.639	242.258	1.05957
	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	Measured	6228.97	7013.53	1.12595
	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Squared	32189.9	37963.6	1.17936
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Rooted	60.0129	64.7371	1.07872
636	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Squared	32187.7	37961	1.17936
	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Rooted	60.0129	64.7371	1.07872
	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	Measured	5713.41	6432.92	1.12593
	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	Ranked	228.639	242.258	1.05957
637	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]
	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	Rooted	60.0129	64.7371	1.07872
	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Squared	32188.2	37961.6	1.17936
	putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]	Measured	7756.51	8731.76	1.12573
638	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Squared	32183.5	37955.7	1.17935
	nucleoside diphosphate kinase a (ec 2.7.4.6) (ndk a) (ndp kinase a) (tumor metastatic process-associated protein) (metastasis inhibition factor nm23) (nm23-h1). [swissprot;acc:p15531]	Measured	7755.69	8730.74	1.12572
	sorting nexin 17. [swissprot;acc:q15036]	Ranked	228.639	242.258	1.05957
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Rooted	60.0129	64.7371	1.07872
639	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	Squared	17618.8	20776.8	1.17924
	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	Rooted	60.0129	64.7371	1.07872
	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	Ranked	217.67	230.596	1.05938
	nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]	Measured	7753.59	8728.13	1.12569
640	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	Rooted	60.0129	64.7371	1.07872
	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	Measured	4811.02	5414.64	1.12547
	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	Ranked	217.67	230.596	1.05938
	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Squared	22848.5	26941.5	1.17914
641	peroxisomal n1-acetyl-spermine/spermidine oxidase. [refseq;acc:nm_152911]	Measured	4810.85	5414.21	1.12542
	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	Ranked	217.67	230.596	1.05938
	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Rooted	60.0129	64.7371	1.07872
	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	Squared	18364.9	21653.8	1.17909
642	6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]		16123.9	19009.7	1.17898
	atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2]	Measured	4810.85	5414.23	1.12542
	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]	Ranked	217.67	230.596	1.05938
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Rooted	64.4857	69.5606	1.0787
643	6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	Squared	16126.5	19012.6	1.17897
	autophagy protein 12-like (apg12-like). [swissprot;acc:o94817]	Rooted	87.4586	81.0798	1.07867
	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	Ranked	217.67	230.596	1.05938
	polyamine oxidase isoform 1; polyamine oxidase; flavin-containing spermine oxidase; putative cyclin g1 interacting protein; flavin containing amine oxidase. [refseq;acc:nm_019025]	Measured	4810.85	5414.23	1.12542
644	6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813]	Squared	16156.3	19046	1.17886
	cgthba protein (-14 gene protein). [swissprot;acc:q12980]	Ranked	217.67	230.596	1.05938

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.