MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Network Comparison Type	Value Type	description	red	Interaction Map	green	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

Rank	Network Comparison Type	description	red	green	Filtered	network_comparison
126	Divided	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	94	114	1	1.21277
		ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	9722.71	11493.8	0	1.18216
	Subtracted	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	12314.9	10489.3		1825.6
		f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	285.684	252.234	1	33.45
127	Divided	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	94	114		1.21277
		trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	9411.34	11119.7	0	1.18152
	Subtracted	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	11732	13530.6		1798.6
		cullin homolog 2 (cul-2). [swissprot;acc:q13617]	285.684	252.234	1	33.45
128	Divided	60s ribosomal protein l39. [swissprot;acc:p02404]	11564.4	9794.29	0	1.18073
		associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	94	114	1	1.21277
	Subtracted	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	285.684	252.234		33.45
		ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	9722.71	11493.8	0	1771.09
129	Divided	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	14222.5	12058.6		1.17945
		neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	94	114	1	1.21277
	Subtracted	60s ribosomal protein l39. [swissprot;acc:p02404]	11564.4	9794.29	0	1770.11
		cullin homolog 1 (cul-1). [swissprot;acc:q13616]	285.684	252.234	1	33.45
130	Divided	enigma protein; lim domain protein. [refseq;acc:nm_005451]	14476.2	17069.5	0	1.17914
		protein hspc134 (protein cda04). [swissprot;acc:q9by43]	94	114	1	1.21277
	Subtracted	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	242.735	276.059		33.324
		potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	14922.7	13174.5	0	1748.2
131	Divided	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	8375.43	9873.58		1.17887
		son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	294.053	242.562	1	1.21228
	Subtracted	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	242.718	276.018		33.3
		integral membrane protein cii-3b. [sptrembl;acc:o75609]	14951.6	13204.2	0	1747.4
132	Divided	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	19048	22389		1.1754
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	350	290	1	1.2069
	Subtracted	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	229.406	196.695		32.711
		myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	10883	12622.8	0	1739.8
133	Divided	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	6814	8009		1.17537
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	350	290	1	1.2069
	Subtracted	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	226.887	194.72		32.167
		mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	17144.8	15405.6	0	1739.2
134	Divided	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	12314.9	10489.3		1.17404
		dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	350	290	1	1.2069
	Subtracted	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	226.884	194.79		32.094
		signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	12157.6	13890.3	0	1732.7
135	Divided	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	12314.9	10489.3		1.17404
		cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	350	290	1	1.2069
	Subtracted	bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	8871.11	10603.2	0	1732.09
		forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	263.215	231.407	1	31.808
136	Divided	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	12335.3	10506.8	0	1.17403
		cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	350	290	1	1.2069
	Subtracted	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	263.215	231.407		31.808
		polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]	12759.4	11028.8	0	1730.6
137	Divided	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	12328.5	10501		1.17403
		ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	350	290	1	1.2069
	Subtracted	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	263.191	231.394		31.797
		maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	16853	15123	0	1730
138	Divided	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	12384.7	10549.4		1.17397
		serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	194.372	234.204	1	1.20493

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.