MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
729	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	no value	Subtracted	208.874	219.708	10.834
730	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	TIMM10	Divided			1.05187
			Subtracted			10.834
731	fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	FH	Divided			1.05187
			Subtracted			10.834
732	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	SEPT8	Divided	124.434	118.318	1.05169
	translin. [swissprot;acc:q15631]	no value	Subtracted	224.385	235.131	10.746
733	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	ACADVL	Divided	164	155.961	1.05154
	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	TSNAX	Subtracted	224.385	235.131	10.746
734	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	PQBP1
	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	no value	Divided	232.601	244.534	1.0513
735	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	RANP1
	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	HEMK1	Subtracted	229.045	218.343	10.702
736	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	no value	Divided	232.601	244.534	1.0513
	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	N6AMT1	Subtracted	228.78	218.091	10.689
737	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	EXOC6B		221.968	211.326	10.642
	septin 10 isoform 1. [refseq;acc:nm_144710]	SEPT10	Divided	125.526	119.402	1.05129
738	exocyst complex component sec15a. [swissprot;acc:q8tag9]	EXOC6	Subtracted	222.138	211.503	10.635
	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	XAB2	Divided	222.825	211.966	1.05123
739	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	PDPK1	Subtracted	272.878	283.472	10.594
	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	PFAS	Divided	223.58	235.027	1.0512
740	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	ATIC
	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	no value	Subtracted	223.463	212.875	10.588
741	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]	PAICS	Divided	223.58	235.027	1.0512
	step ii splicing factor slu7. [refseq;acc:nm_006425]	SLU7	Subtracted	223.463	212.875	10.588
742	brain protein 44. [swissprot;acc:o95563]	BRP44	Divided	126.215	120.078	1.05111
	histone deacetylase 2 (hd2). [swissprot;acc:q92769]	no value	Subtracted	226.003	215.541	10.462
743	multiple coagulation factor deficiency 2; neural stem cell derived neuronal survival protein; multiple coagulation factor deficiency protein 2. [refseq;acc:nm_139279]	MCFD2		225.996	215.535	10.461
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7	Divided	126.215	120.078	1.05111
744	dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	no value	Subtracted	225.996	215.535	10.461
	septin 6. [swissprot;acc:q14141]	SEPT6	Divided	126.604	120.463	1.05098
745	histone deacetylase 1 (hd1). [swissprot;acc:q13547]	HDAC1	Subtracted	225.989	215.53	10.459
	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	SLC35B1	Divided	214.679	225.568	1.05072
746	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	EIF3I		250.465	238.38	1.0507
	protein tara (trio-associated repeat on actin) (hrihfb2122). [swissprot;acc:q9h2d6]	TRIOBP	Subtracted	213.804	224.226	10.422
747	rho interacting protein 3. [refseq;acc:nm_015134]	no value		213.803	224.224	10.421
	trinucleotide repeat containing 15. [refseq;acc:nm_015575]		Divided	250.465	238.38	1.0507
748	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	FBL		245.246	233.483	1.05038
	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	PRPF3	Subtracted	222.082	211.707	10.375
749	dnaj homolog subfamily b member 4 (heat shock 40 kda protein 1 homolog) (heat shock protein 40 homolog) (hsp40 homolog). [swissprot;acc:q9udy4]	DNAJB4		210.946	221.225	10.279
	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	EXOC6B	Divided	221.968	211.326	1.05036
750	cab2. [refseq;acc:nm_033419]	PERLD1	Subtracted	210.946	221.225	10.279
	exocyst complex component sec15a. [swissprot;acc:q8tag9]	EXOC6	Divided	222.138	211.503	1.05028
751	dnaj homolog subfamily b member 5 (heat shock protein hsp40-3) (heat shock protein cognate 40) (hsc40) (hsp40-2). [swissprot;acc:o75953]	DNAJB5	Subtracted	210.946	221.225	10.279
	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	no value	Divided	223.463	212.875	1.04974
752	dnaj homolog subfamily b member 1 (heat shock 40 kda protein 1) (heat shock protein 40) (hsp40) (dnaj protein homolog 1) (hdj-1). [swissprot;acc:p25685]	DNAJB1	Subtracted	210.946	221.225	10.279
	step ii splicing factor slu7. [refseq;acc:nm_006425]	SLU7	Divided	223.463	212.875	1.04974
753	eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]	ETF1	Subtracted	210.946	221.225	10.279
	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	LBP	Divided	224.434	235.583	1.04968
754	microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]	SPCS2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.