MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Interaction Map	green	Network Comparison Type	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 8289 in total

Value Type  : Measured
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	green	red	network_comparison
251	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]	Low confidence	9058.09	8527.55	1.06221
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	High confidence	7859.6	6417.18	1.22477
252	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Low confidence	9018.94	8492.92	1.06194
	crk-like protein. [swissprot;acc:p46109]	High confidence	7859.6	6417.18	1.22477
253	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	Low confidence	8732.25	8223.39	1.06188
	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	High confidence	7859.59	6417.18	1.22477
254	dj842g6.2 (novel protein imilar to sel1l (sel-1 (suppressor of lin-12, c.elegans)-like)) (fragment). [sptrembl;acc:q9ugd3]	Low confidence	8727.87	8219.97	1.06179
	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	High confidence	7859.6	6417.18	1.22477
255	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]
	sel-1 homolog precursor (suppressor of lin-12-like protein) (sel-1l). [swissprot;acc:q9ubv2]	Low confidence	8727.84	8219.95	1.06179
256	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]		8723.91	8216.87	1.06171
	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	High confidence	7859.51	6417.19	1.22476
257	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]		7858.12	6417.31	1.22452
	synaptojanin 1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1). [swissprot;acc:o43426]	Low confidence	8579.93	8082.34	1.06157
258	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]		9818.95	9249.74	1.06154
	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	High confidence	7857.93	6417.33	1.22449
259	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]		7852.52	6417.81	1.22355
	oligophrenin 1. [swissprot;acc:o60890]	Low confidence	6824.22	6428.7	1.06152
260	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]		9814.59	9246.23	1.06147
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	High confidence	5193.42	4244.95	1.22343
261	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	Low confidence	9379.17	8837.18	1.06133
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	High confidence	5192.61	4247.36	1.22255
262	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]		20431.7	24896.4	1.21852
	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Low confidence	6834.37	6440.08	1.06122
263	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]		7877.49	7424.14	1.06106
	trs85 homolog. [swissprot;acc:q9y2l5]	High confidence	20431.7	24896.4	1.21852
264	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		4094.57	4987.58	1.2181
	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]	Low confidence	6786.96	6396.44	1.06105
265	synaptojanin 2 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2) (fragment). [swissprot;acc:o15056]		8573.8	8081.02	1.06098
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	High confidence	20369.9	24806.9	1.21782
266	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	Low confidence	9353.9	8817.03	1.06089
	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	High confidence	20369.9	24806.9	1.21782
267	choline/ethanolaminephosphotransferase. [refseq;acc:nm_006090]	Low confidence	9348.71	8813.83	1.06069
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	High confidence	11523	14021.4	1.21682
268	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]		20127.8	24473.9	1.21593
	reversion-inducing cysteine-rich protein with kazal motifs precursor (hreck) (suppressor of tumorigenicity 15) (st15). [swissprot;acc:o95980]	Low confidence	9348.71	8813.83	1.06069
269	choline phosphotransferase 1; cholinephosphotransferase 1 alpha; cholinephosphotransferase 1. [refseq;acc:nm_020244]		9348.9	8813.95
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	High confidence	5575.52	4590.18	1.21466
270	carboxypeptidase a5. [refseq;acc:nm_080385]	Low confidence	9345.51	8811.88	1.06056
	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	High confidence	19479.8	23640.2	1.21358
271	carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	Low confidence	9345.26	8811.69	1.06055
	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	High confidence	3093.78	2554.89	1.21092
272	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor (ec 1.5.1.12) (p5c dehydrogenase). [swissprot;acc:p30038]	Low confidence	10526.2	11162	1.0604
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	High confidence	4669.27	3858.52	1.21012
273	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		3870.8	3199.4	1.20985
	phospholipase a-2-activating protein (plap) (pla2p). [swissprot;acc:q9y263]	Low confidence	10526.2	11162	1.0604
274	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	High confidence	2579.49	3119.98	1.20953
	small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356]	Low confidence	8184.75	7718.85	1.06036
275	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	High confidence	2579.49	3119.98	1.20953
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	Low confidence	7958.12	7506.19	1.06021

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.