MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3408 to 3457 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
852	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	Squared	31100.1	36086.4	1.16033
853	apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	Measured	4078.45	4502.32	1.10393
	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	Squared	31100.1	36086.4	1.16033
	target of egr1, member 1 (nuclear); target of egr1, member 1. [refseq;acc:nm_025077]	Rooted	64.0287	68.0566	1.06291
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Ranked	108.289	112.772	1.0414
854	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	importin alpha-3 subunit (karyopherin alpha-3 subunit) (srp1-gamma). [swissprot;acc:o00505]	Rooted	64.0316	68.0597	1.06291
	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	Squared	31100.2	36086.5	1.16033
	uba/ubx 33.3 kda protein. [swissprot;acc:q04323]	Measured	6562.98	7242.37	1.10352
855	ero1-like. [refseq;acc:nm_014584]
	espin. [refseq;acc:nm_031475]	Squared	31100.1	36086.4	1.16033
	importin alpha-4 subunit (karyopherin alpha-4 subunit) (qip1 protein). [swissprot;acc:o00629]	Rooted	64.0262	68.0537	1.0629
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	Ranked	178.514	171.42	1.04138
856	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	Squared	31100.1	36086.4	1.16033
	heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]	Measured	5210.58	5749.33	1.1034
	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	Rooted	58.5944	62.2766	1.06284
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Ranked	215.028	206.623	1.04068
857	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	Rooted	58.6002	62.2793	1.06278
	n-deacetylase/n-sulfotransferase (heparan glucosaminyl) 3. [refseq;acc:nm_004784]	Measured	5210.58	5749.33	1.1034
	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	Squared	31100.1	36086.4	1.16033
	putatative 28 kda protein. [refseq;acc:nm_020143]	Ranked	227.241	236.467	1.0406
858	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	Rooted	65.1843	69.2736	1.06273
	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	Squared	31100.1	36086.4	1.16033
	n-deacetylase/n-sulfotransferase 4. [refseq;acc:nm_022569]	Measured	5210.58	5749.33	1.1034
	syntaxin 12. [refseq;acc:nm_177424]	Ranked	217.446	208.997	1.04043
859	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	224.958	1.04031
	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	Squared	31100.1	36086.4	1.16033
	heparan sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.8) (n-hsst) (hsnst) ([heparan sulfate]-glucosamine n-sulfotransferase) (n-heparan sulfate sulfotransferase) (glucosaminyl n-deacetylase/n- sulfotransferase). [swissprot;acc:p52848]	Measured	5210.58	5749.33	1.1034
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	Rooted	53.3429	50.2017	1.06257
860	60s ribosomal protein l18a. [swissprot;acc:q02543]	Ranked	234.025	224.958	1.04031
	neurotrypsin precursor (ec 3.4.21.-) (motopsin) (leydin). [swissprot;acc:p56730]	Squared	24242.8	28127.6	1.16025
	protein cdc27hs (cell division cycle protein 27 homolog) (h-nuc). [swissprot;acc:p30260]	Measured	5210.58	5749.33	1.1034
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	Rooted	60.6929	64.4864	1.0625
861	40s ribosomal protein s19. [swissprot;acc:p39019]	Ranked	234.025	224.958	1.04031
	apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	Rooted	51.8245	55.0559	1.06235
	bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	Measured	5734.15	6326.41	1.10329
	ring finger protein 44. [refseq;acc:nm_014901]	Squared	24242.8	28127.6	1.16025
862	60s ribosomal protein l31. [swissprot;acc:p12947]	Ranked	234.025	224.958	1.04031
	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	Rooted	76.0455	80.7777	1.06223
	phosphatidylinositol 3-kinase regulatory alpha subunit (pi3-kinase p85-alpha subunit) (ptdins-3-kinase p85-alpha) (pi3k). [swissprot;acc:p27986]	Squared	24242.8	28127.6	1.16025
	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	Measured	4076.72	4497.74	1.10327
863	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	Ranked	240.194	230.957	1.03999
	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	Rooted	62.7551	66.6474	1.06202
	neurotrypsin precursor (ec 3.4.21.-) (motopsin) (leydin). [swissprot;acc:p56730]	Measured	5595.65	6173.23	1.10322
	ring finger protein 38. [refseq;acc:nm_022781]	Squared	24242.8	28127.6	1.16025
864	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	Ranked	240.194	230.957	1.03999
	phosphatidylinositol 3-kinase regulatory gamma subunit (pi3-kinase p85-gamma subunit) (ptdins-3-kinase p85-gamma) (p55pik). [swissprot;acc:q92569]	Squared	24242.8	28127.6	1.16025
	ring finger protein 44. [refseq;acc:nm_014901]	Measured	5595.65	6173.23	1.10322
	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	Rooted	62.7551	66.6474	1.06202
865	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.