MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Network Comparison Type	Value Type	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1610 to 1659 of 6456 in total

Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

Rank	description	Network Comparison Type	red	network_comparison	green
805	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	Subtracted	212.386	9.399	221.785
806	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Divided		1.04425
	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	Subtracted	267.447	9.326	276.773
807	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	Divided	212.386	1.04425	221.785
	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]	Subtracted	218.521	9.275	227.796
808	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]		223.186	9.274	213.912
	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	Divided	212.386	1.04425	221.785
809	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Subtracted	233.298	9.273	242.571
	syntaxin 16 (syn16). [swissprot;acc:o14662]	Divided	212.386	1.04425	221.785
810	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	Subtracted	240.194	9.237	230.957
811	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]
	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	Divided	212.386	1.04425	221.785
812	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]
	putatative 28 kda protein. [refseq;acc:nm_020143]	Subtracted	227.241	9.226	236.467
813	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	Divided	212.386	1.04425	221.785
	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Subtracted	228.599	9.2	219.399
814	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	Divided	212.386	1.04425	221.785
	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	Subtracted	244.155	9.195	234.96
815	eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]		246.354	9.131	237.223
	syntaxin 1b. [swissprot;acc:q15531]	Divided	212.386	1.04425	221.785
816	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	Subtracted	246.354	9.131	237.223
	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	Divided	212.386	1.04425	221.785
817	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	Subtracted	110.689	9.076	101.613
818	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	9.067	224.958
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Divided	168.592	1.04422	161.452
819	60s ribosomal protein l18a. [swissprot;acc:q02543]	Subtracted	234.025	9.067	224.958
	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	Divided	228.563	1.04421	238.668
820	40s ribosomal protein s19. [swissprot;acc:p39019]	Subtracted	234.025	9.067	224.958
	mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	Divided	221.716	1.04413	231.501
821	60s ribosomal protein l31. [swissprot;acc:p12947]	Subtracted	234.025	9.067	224.958
	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]	Divided	221.676	1.0441	231.453
822	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]		243.067	1.04408	232.805
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Subtracted	55	9	46
823	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]
	transcription factor iib. [refseq;acc:nm_013242]	Divided	206.068	1.04354	197.471
824	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Subtracted	55	9	46
	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	Divided	206.068	1.04354	197.471
825	40s ribosomal protein s3a. [swissprot;acc:p49241]	Subtracted	225.689	8.985	234.674
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Divided	206.214	1.04352	197.614
826	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]		223.186	1.04335	213.912
	dna-directed rna polymerase ii 13.3 kda polypeptide (ec 2.7.7.6) (rpb11). [swissprot;acc:p52435]	Subtracted	230.811	8.974	239.785
827	jm1 protein. [refseq;acc:nm_014008]		219.762	8.956	210.806
	loh1cr12. [refseq;acc:nm_058169]	Divided	230.087	1.0431	220.579
828	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Subtracted	135.087	8.954	144.041
	unr protein. [swissprot;acc:o75534]	Divided	230.087	1.0431	220.579
829	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	Subtracted	252.873	8.948	261.821
	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Divided	135.844	1.04288	130.259
830	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]		231.734	1.0428	222.222

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.