MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 727 to 776 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
364	cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	Subtracted	253.197	233.539	19.658
	dna-directed rna polymerase ii 140 kda polypeptide (ec 2.7.7.6) (rna polymerase ii subunit 2) (rpb2). [swissprot;acc:p30876]	Divided	266.617	243.208	1.09625
365	60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]		266.07	242.744	1.09609
	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	Subtracted	253.197	233.539	19.658
366	40s ribosomal protein s5. [swissprot;acc:p46782]	Divided	265.756	242.473	1.09602
	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	Subtracted	253.197	233.539	19.658
367	dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]		238.407	218.827	19.58
	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	Divided	256.627	234.146	1.09601
368	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	Subtracted	238.407	218.827	19.58
	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	Divided	265.715	242.66	1.09501
369	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]		265.104	242.159	1.09475
	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	Subtracted	259.525	239.977	19.548
370	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]		238.358	218.818	19.54
	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	Divided	265.104	242.159	1.09475
371	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Subtracted	166.661	186.172	19.511
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Divided	170.42	186.52	1.09447
372	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	Subtracted	259.038	239.709	19.329
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Divided	170.42	186.52	1.09447
373	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]		265.255	242.37	1.09442
	dynactin 4. [refseq;acc:nm_032486]	Subtracted	252.253	233.142	19.111
374	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]		267.226	248.152	19.074
	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Divided	244.168	267.208	1.09436
375	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	Subtracted	267.226	248.152	19.074
	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]	Divided	265.516	242.686	1.09407
376	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	Subtracted	267.226	248.152	19.074
	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	Divided	234.945	257.017	1.09395
377	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]		265.481	242.691	1.09391
	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	Subtracted	267.226	248.152	19.074
378	60s ribosomal protein l30. [swissprot;acc:p04645]	Divided	265.365	242.593	1.09387
	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	Subtracted	267.226	248.152	19.074
379	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	Divided	264.163	241.509	1.0938
	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	Subtracted	267.226	248.152	19.074
380	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]
	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]	Divided	264.79	242.109	1.09368
381	thymic stromal co-transporter. [refseq;acc:nm_033051]	Subtracted	267.226	248.152	19.074
	transcription initiation factor tfiid 55 kda subunit (tafii-55) (tafii55). [swissprot;acc:q15545]	Divided	183.423	200.586	1.09357
382	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	Subtracted	234.808	253.852	19.044
	tata box binding protein-associated factor, rna polymerase ii, q; taf7-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 50 kd; tbp-associated factor, rna polymerase ii, q. [refseq;acc:nm_024885]	Divided	183.66	200.791	1.09328
383	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]		217.739	237.862	1.09242
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]	Subtracted	255.113	236.245	18.868
384	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]		208.756	227.575	18.819
	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Divided	244.236	266.421	1.09083
385	small nuclear ribonucleoprotein f (snrnp-f) (sm protein f) (sm-f) (smf). [swissprot;acc:q15356]	Subtracted	208.756	227.575	18.819
	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Divided	244.236	266.421	1.09083
386	40s ribosomal protein s14 (pro2640). [swissprot;acc:p06366]		264.11	242.238	1.09029
	40s ribosomal protein s9. [swissprot;acc:p46781]	Subtracted	257.784	238.986	18.798
387	40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232]	Divided	264.11	242.238	1.09029
	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Subtracted	75.3531	56.6768	18.6763
388	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]		75.3948	56.7244	18.6704
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Divided	208.756	227.575	1.09015

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.