MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 244 to 293 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
61	necdin. [swissprot;acc:q99608]	Squared	219048	129762	1.68808
62	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Measured	4489.19	2765.82	1.6231
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Ranked	266.865	336.181	1.25974
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Squared	219048	129762	1.68808
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Rooted	43.4519	31.7522	1.36847
63	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Ranked	266.865	336.178	1.25973
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Rooted	43.4554	31.7576	1.36835
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Squared	219048	129762	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Measured	4489.19	2765.82	1.6231
64	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Rooted	63.8686	47.2654	1.35128
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Measured	4489.19	2765.82	1.6231
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Ranked	266.868	336.159	1.25965
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Squared	219048	129762	1.68808
65	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Rooted	63.8686	47.2654	1.35128
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Ranked	267.136	336.077	1.25807
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Squared	219048	129762	1.68808
	neuralized-like. [refseq;acc:nm_004210]	Measured	1657.68	2690.25	1.6229
66	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Rooted	63.8686	47.2654	1.35128
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Ranked	267.136	336.077	1.25807
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Squared	219048	129762	1.68808
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Measured	1991.03	3221.38	1.61795
67	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		6475.5	10307.5	1.59177
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Ranked	267.14	336.075	1.25805
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Squared	219048	129762	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Rooted	63.8686	47.2654	1.35128
68	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Measured	6475.5	10307.5	1.59177
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Rooted	63.8686	47.2654	1.35128
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Ranked	267.139	336.075	1.25805
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Squared	219048	129762	1.68808
69	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Ranked	267.14	336.075	1.25805
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Squared	219048	129762	1.68808
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	Rooted	27.9136	37.2872	1.33581
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Measured	6475.5	10307.5	1.59177
70	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	Rooted	27.9136	37.2872	1.33581
	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	Ranked	267.142	336.074	1.25804
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Squared	219048	129762	1.68808
71	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	Rooted	27.9136	37.2872	1.33581
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	Ranked	267.144	336.073	1.25802
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Squared	219048	129762	1.68808
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Measured	4556.78	2945.26	1.54716
72	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Ranked	267.144	336.073	1.25802
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Squared	219048	129762	1.68808
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Rooted	27.9136	37.2872	1.33581
	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	Measured	4556.79	2945.28	1.54715
73	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Ranked	288	362	1.25694
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Squared	219048	129762	1.68808
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Rooted	27.9136	37.2872	1.33581
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	Measured	4556.83	2945.38	1.54711
74	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Ranked	288	362	1.25694

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.