MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3708 to 3757 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1854	EIF2B5	translation initiation factor eif-2b epsilon subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q13144]	Divided	222.215	224.637	1.0109
1855	ATP11A	potential phospholipid-transporting atpase ih (ec 3.6.3.1) (atpase class i type 11a) (atpase is). [swissprot;acc:p98196]	Subtracted	212.455	210.113	2.342
	GRSF1	g-rich sequence factor-1 (grsf-1). [swissprot;acc:q12849]	Divided	217.891	215.542	1.0109
1856	APEX1	dna-(apurinic or apyrimidinic site) lyase (ec 4.2.99.18) (ap endonuclease 1) (apex nuclease) (apen) (ref-1 protein). [swissprot;acc:p27695]	Subtracted	211.882	209.544	2.338
	HNRPH3	heterogeneous nuclear ribonucleoprotein h3 (hnrnp h3) (hnrnp 2h9). [swissprot;acc:p31942]	Divided	217.892	215.543	1.0109
1857	EIF2B3	translation initiation factor eif-2b gamma subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q9nr50]		222.215	224.637
	GMPPB	gdp-mannose pyrophosphorylase b isoform 1; mannose-1-phosphate guanylyltransferase; amphoterin induced gene 3. [refseq;acc:nm_013334]	Subtracted	222.842	225.17	2.328
1858	GMPPA	gdp-mannose pyrophosphorylase a; mannose-1-phosphate guanylyltransferase (gdp). [refseq;acc:nm_013335]
	HNRPF	heterogeneous nuclear ribonucleoprotein f (hnrnp f). [swissprot;acc:p52597]	Divided	217.893	215.545	1.01089
1859	HNRPH1	heterogeneous nuclear ribonucleoprotein h (hnrnp h). [swissprot;acc:p31943]		217.895	215.547
	SARM1	sterile alpha and tir motif containing 1; sterile alpha and heat/armadillo motif protein, ortholog of drosophila. [refseq;acc:nm_015077]	Subtracted	220.896	218.577	2.319
1860	FXR2	fragile x mental retardation syndrome related protein 2. [swissprot;acc:p51116]		202.386	200.086	2.3
	HNRPH2	heterogeneous nuclear ribonucleoprotein h' (hnrnp h') (ftp-3). [swissprot;acc:p55795]	Divided	217.895	215.547	1.01089
1861	CYB5R2	cytochrome b5 reductase b5r.2. [refseq;acc:nm_016229]		210.856	213.147	1.01087
	FXR1	fragile x mental retardation syndrome related protein 1. [swissprot;acc:p51114]	Subtracted	202.386	200.086	2.3
1862	CYB5R1	cytochrome b5 reductase 1 (b5r.1). [refseq;acc:nm_016243]	Divided	210.856	213.147	1.01087
	NUP43	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	Subtracted	202.393	200.094	2.299
1863	CYB5R3	nadh-cytochrome b5 reductase (ec 1.6.2.2) (b5r). [swissprot;acc:p00387]	Divided	210.856	213.147	1.01087
	FMR1	fragile x mental retardation 1 protein (protein fmr-1) (fmrp). [swissprot;acc:q06787]	Subtracted	202.41	200.115	2.295
1864	OLA1	putative gtp-binding protein ptd004 (pro2455). [swissprot;acc:q9ntk5]		215.081	217.373	2.292
	PUF60	fuse-binding protein-interacting repressor isoform b; siah binding protein 1; pyrimidine tract binding splicing factor; ro ribonucleoprotein-binding protein 1; poly-u binding splicing factor puf60. [refseq;acc:nm_014281]	Divided	203.071	200.89	1.01086
1865	CYB5R2	cytochrome b5 reductase b5r.2. [refseq;acc:nm_016229]	Subtracted	210.856	213.147	2.291
	EIF2S3	eukaryotic translation initiation factor 2 subunit 3 (eukaryotic translation initiation factor 2 gamma subunit) (eif-2-gamma). [swissprot;acc:p41091]	Divided	221.639	224.046	1.01086
1866	CYB5R1	cytochrome b5 reductase 1 (b5r.1). [refseq;acc:nm_016243]	Subtracted	210.856	213.147	2.291
	EIF2B4	translation initiation factor eif-2b delta subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q9ui10]	Divided	221.725	224.133	1.01086
1867	no value	multisynthetase complex auxiliary component p38 (jtv-1 protein) (pro0992). [swissprot;acc:q13155]		203.071	200.89
	CYB5R3	nadh-cytochrome b5 reductase (ec 1.6.2.2) (b5r). [swissprot;acc:p00387]	Subtracted	210.856	213.147	2.291
1868	RPL28	60s ribosomal protein l28. [swissprot;acc:p46779]		215.896	213.61	2.286
	TPD52L3	protein kinase nyd-sp25. [refseq;acc:nm_033516]	Divided	207.642	209.895	1.01085
1869	ICT1	immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197]	Subtracted	218.414	216.131	2.283
	LANCL2	lanc lantibiotic synthetase component c-like 2; testis-specific adriamycin sensitivity protein; lanc (bacterial lantibiotic synthetase component c)-like 2; g protein-coupled receptor 69b. [refseq;acc:nm_018697]	Divided	220.107	217.75	1.01082
1870	LANCL1	lanthionine synthetase c-like protein 1; g protein-coupled receptor 69a; lanc (bacterial lantibiotic synthetase component c)-like 1; lanc (bacterial lantibiotic synthetase component). [refseq;acc:nm_006055]
	NUCB1	nucleobindin 1 precursor (calnuc). [swissprot;acc:q02818]	Subtracted	212.186	214.467	2.281
1871	CLPX	atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031]	Divided	222.819	225.228	1.01081
	MLH1	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	Subtracted	212.186	214.467	2.281
1872	NUCB2	nucleobindin 2 precursor (dna-binding protein nefa). [swissprot;acc:p80303]
	POLDIP2	dna polymerase delta p38 subunit. [refseq;acc:nm_015584]	Divided	222.819	225.228	1.01081
1873	no value	scratch; scratch 1. [refseq;acc:nm_031309]		210.55	208.305	1.01078
	NME2P1	putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]	Subtracted	193.1	190.823	2.277
1874	no value	nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]		193.138	190.861
		williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	Divided	223.862	226.271	1.01076
1875	NME2	nucleoside diphosphate kinase a (ec 2.7.4.6) (ndk a) (ndp kinase a) (tumor metastatic process-associated protein) (metastasis inhibition factor nm23) (nm23-h1). [swissprot;acc:p15531]	Subtracted	193.111	190.834	2.277
	NSUN5	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]	Divided	223.862	226.271	1.01076
1876	HSD17B4	estradiol 17 beta-dehydrogenase 4 (ec 1.1.1.62) (17-beta-hsd 4) (17-beta-hydroxysteroid dehydrogenase 4). [swissprot;acc:p51659]	Subtracted	185.276	187.534	2.258
	NSUN5B	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]	Divided	223.862	226.271	1.01076
1877	NUCB1	nucleobindin 1 precursor (calnuc). [swissprot;acc:q02818]		212.186	214.467	1.01075
	TPD52L3	protein kinase nyd-sp25. [refseq;acc:nm_033516]	Subtracted	207.642	209.895	2.253
1878	no value	scratch; scratch 1. [refseq;acc:nm_031309]		210.55	208.305	2.245
	MLH1	dna mismatch repair protein mlh1 (mutl protein homolog 1). [swissprot;acc:p40692]	Divided	212.186	214.467	1.01075
1879	no value	dj850e9.1 (novel c2h2 type zinc finger protein similar to drosophila scratch (scrt), slug and xenopus snail) (fragment). [sptrembl;acc:q9nq03]	Subtracted	210.592	208.355	2.237

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.