MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2280 to 2329 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
1140	dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804]	High confidence	218.484	212.675	1.02731
1141	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]
	histone h1.5 (histone h1a). [swissprot;acc:p16401]	Low confidence	198.047	193.51	1.02345
1142	histone h1.4 (histone h1b). [swissprot;acc:p10412]		198.05	193.513
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]	High confidence	218.484	212.675	1.02731
1143	histone h1.1. [swissprot;acc:q02539]	Low confidence	198.054	193.517	1.02344
	secretory pathway component sec31b-1. [refseq;acc:nm_015490]	High confidence	218.484	212.675	1.02731
1144	dna-binding protein a (cold shock domain protein a) (single-strand dna binding protein nf-gmb). [swissprot;acc:p16989]	Low confidence	203.991	199.319	1.02344
	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]	High confidence	218.484	212.675	1.02731
1145	u6 snrna-associated sm-like protein lsm3 (mds017). [swissprot;acc:q9y4z1]	Low confidence	201.836	197.216	1.02343
	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864]	High confidence	218.481	212.675	1.0273
1146	dna replication licensing factor mcm7 (cdc47 homolog) (p1.1-mcm3). [swissprot;acc:p33993]	Low confidence	201.363	196.754	1.02343
	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	High confidence	218.483	212.676	1.0273
1147	inositol polyphosphate-5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type iv; phosphatidylinositol (4,5) bisphosphate 5-phosphatase. [refseq;acc:nm_019892]	Low confidence	198.92	194.368	1.02342
	peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [swissprot;acc:o75381]	High confidence	208.651	203.109	1.02729
1148	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	Low confidence	200.371	195.785	1.02342
	ubiquitin. [swissprot;acc:p02248]	High confidence	209.061	203.518	1.02724
1149	bystin. [swissprot;acc:q13895]		239.505	233.185	1.0271
	sh3-containing grb2-like protein 3 (sh3 domain protein 2c) (een-b2). [swissprot;acc:q99963]	Low confidence	203.665	199.007	1.02341
1150	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]		178.634	174.552	1.02339
	sorting nexin 1. [swissprot;acc:q13596]	High confidence	209.868	215.522	1.02694
1151	metaxin 1. [swissprot;acc:q13505]		199.552	204.925	1.02693
	putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]	Low confidence	199.769	195.206	1.02338
1152	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	High confidence	221.939	216.143	1.02682
	transcription initiation factor tfiid 28 kda subunit (tafii-28) (tafii28) (tfiid subunit p30-beta). [swissprot;acc:q15544]	Low confidence	197.295	192.791	1.02336
1153	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	High confidence	221.93	216.146	1.02676
	nucleoside diphosphate kinase a (ec 2.7.4.6) (ndk a) (ndp kinase a) (tumor metastatic process-associated protein) (metastasis inhibition factor nm23) (nm23-h1). [swissprot;acc:p15531]	Low confidence	199.769	195.209	1.02336
1154	homeobox protein otx2. [swissprot;acc:p32243]		205.64	200.948	1.02335
	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	High confidence	224.307	230.242	1.02646
1155	homeobox protein otx1. [swissprot;acc:p32242]	Low confidence	205.629	200.937	1.02335
	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	High confidence	224.307	230.242	1.02646
1156	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]
	cone-rod homeobox protein. [swissprot;acc:o43186]	Low confidence	205.625	200.934	1.02335
1157	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	High confidence	224.307	230.242	1.02646
	tfiih basal transcription factor complex helicase subunit (ec 3.6.1.-) (dna-repair protein complementing xp-d cells) (xeroderma pigmentosum group d complementing protein) (cxpd) (dna excision repair protein ercc-2). [swissprot;acc:p18074]	Low confidence	201.354	196.761	1.02334
1158	diaphanous protein homolog 1 (diaphanous-related formin 1) (drf1). [swissprot;acc:o60610]		200.185	195.622	1.02333
	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	High confidence	221.877	216.167	1.02641
1159	4-hydroxyphenylpyruvate dioxygenase (ec 1.13.11.27) (4hppd) (hpd) (hppdase). [swissprot;acc:p32754]	Low confidence	203.422	198.786	1.02332
	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	High confidence	170.28	165.898	1.02641
1160	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]		208.55	214.041	1.02633
	mitochondrial carnitine/acylcarnitine carrier protein (carnitine/acylcarnitine translocase) (cac). [swissprot;acc:o43772]	Low confidence	201.192	196.61	1.02331
1161	kappa b-ras 1. [refseq;acc:nm_020345]	High confidence	220.758	215.097	1.02632
	nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]	Low confidence	199.768	195.217	1.02331
1162	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]		192.287	187.907
	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]	High confidence	220.758	215.097	1.02632
1163	snare associated protein snapin. [refseq;acc:nm_012437]
	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Low confidence	201.482	196.897	1.02329
1164	adp-ribosylation factor 3. [swissprot;acc:p16587]		202.869	198.252
	transducin-like enhancer protein 4. [swissprot;acc:q04727]	High confidence	219.438	213.818	1.02628
1165	adp-ribosylation factor 4. [swissprot;acc:p18085]	Low confidence	202.831	198.216	1.02328

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.