MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 201 to 250 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
101	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Divided	88.2482	110.265	1.24949
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Subtracted	204.641	161.051	43.59
102	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]		204.642	161.068	43.574
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Divided	88.2482	110.265	1.24949
103	transcription factor jun-b. [swissprot;acc:p17275]	Subtracted	201.144	158.868	42.276
	trophinin. [swissprot;acc:q12816]	Divided	88.2482	110.265	1.24949
104	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]		252.371	202.016	1.24926
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	Subtracted	256.228	298.438	42.21
105	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	Divided	266.716	333.165	1.24914
	transcription factor jun-d. [swissprot;acc:p17535]	Subtracted	200.941	158.941	42
106	nostrin. [refseq;acc:nm_052946]		209.299	249.187	39.888
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Divided	252.329	202.004	1.24913
107	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Subtracted	209.299	249.187	39.888
	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Divided	252.309	201.998	1.24907
108	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]		252.296	201.995	1.24902
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	Subtracted	209.299	249.187	39.888
109	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	Divided	266.933	333.281	1.24856
110	deltex 2. [refseq;acc:nm_020892]		333.144	267.393	1.2459
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	Subtracted	209.299	249.187	39.888
111	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	Divided	332.925	267.274	1.24563
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	Subtracted	209.299	249.187	39.888
112	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]		275.754	235.908	39.846
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	Divided	332.874	267.246	1.24557
113	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Subtracted	194.372	234.204	39.832
114	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	37.447
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Divided	332.874	267.246	1.24557
115	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Subtracted	277.546	240.461	37.085
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Divided	332.874	267.246	1.24557
116	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]		268.565	334.483	1.24545
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Subtracted	208.52	171.595	36.925
117	high-mobility group 20a. [refseq;acc:nm_018200]		208.588	171.778	36.81
	neuralized-like. [refseq;acc:nm_004210]	Divided	332.326	266.948	1.24491
118	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]		284.753	228.934	1.24382
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Subtracted	274.027	237.79	36.237
119	adiponectin receptor 2. [refseq;acc:nm_024551]		281.582	246.371	35.211
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Divided	318.982	259.004	1.23157
120	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Subtracted	227.199	192.715	34.484
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided	269.278	327.709	1.21699
121	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]		269.254	327.655	1.2169
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	Subtracted	227.202	192.823	34.379
122	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		199.949	234.187	34.238
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided	269.248	327.642	1.21688
123	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]		269.23	327.601	1.21681
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Subtracted	227.032	193.056	33.976
124	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	208.52	171.595	1.21519
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Subtracted	285.684	252.234	33.45
125	high-mobility group 20a. [refseq;acc:nm_018200]	Divided	208.588	171.778	1.21429
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Subtracted	285.684	252.234	33.45

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.