MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 530 to 579 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
265	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Divided	202.459	225.217	1.11241
266	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	Subtracted	266.662	243.12	23.542
	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	Divided	267.88	241.07	1.11121
267	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	Subtracted	266.661	243.12	23.541
	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	Divided	267.88	241.07	1.11121
268	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		244.167	271.016	1.10996
	protein arginine n-methyltransferase 3 (ec 2.1.1.-) (fragment). [swissprot;acc:o60678]	Subtracted	265.136	241.625	23.511
269	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]
	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	Divided	267.352	241.373	1.10763
270	40s ribosomal protein s3. [swissprot;acc:p23396]	Subtracted	265.119	241.612	23.507
	fad synthetase. [refseq;acc:nm_025207]	Divided	267.352	241.373	1.10763
271	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]
	protein transport protein sec61 gamma subunit. [swissprot;acc:p38384]	Subtracted	266.559	243.072	23.487
272	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	Divided	267.352	241.373	1.10763
	mitochondrial ribosomal protein l17; lyst-interacting protein lip2. [refseq;acc:nm_022061]	Subtracted	266.248	242.83	23.418
273	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Divided	267.352	241.373	1.10763
	dna-directed rna polymerase ii 140 kda polypeptide (ec 2.7.7.6) (rna polymerase ii subunit 2) (rpb2). [swissprot;acc:p30876]	Subtracted	266.617	243.208	23.409
274	60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]		266.07	242.744	23.326
	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Divided	267.352	241.373	1.10763
275	40s ribosomal protein s5. [swissprot;acc:p46782]	Subtracted	265.756	242.473	23.283
	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Divided	267.352	241.373	1.10763
276	60s ribosomal protein l32. [swissprot;acc:p02433]		266.969	241.13	1.10716
	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]	Subtracted	235.183	258.437	23.254
277	40s ribosomal protein s29. [swissprot;acc:p30054]	Divided	267.642	241.849	1.10665
	60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	Subtracted	262.434	239.277	23.157
278	40s ribosomal protein s11. [swissprot;acc:p04643]	Divided	267.088	241.399	1.10642
	myelin gene expression factor 2. [refseq;acc:nm_016132]	Subtracted	258.476	235.383	23.093
279	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Divided	228.42	252.644	1.10605
	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	Subtracted	265.715	242.66	23.055
280	metastasis-associated protein mta1. [swissprot;acc:q13330]	Divided	228.356	252.512	1.10578
	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Subtracted	244.168	267.208	23.04
281	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]		265.104	242.159	22.945
	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Divided	267.335	241.808	1.10557
282	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]		228.297	252.39	1.10553
	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	Subtracted	265.104	242.159	22.945
283	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]		265.255	242.37	22.885
	60s ribosomal protein l11. [swissprot;acc:p39026]	Divided	267.346	241.828	1.10552
284	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]		203.235	224.657	1.10541
	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]	Subtracted	265.516	242.686	22.83
285	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]		265.481	242.691	22.79
	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	Divided	203.242	224.647	1.10532
286	60s ribosomal protein l30. [swissprot;acc:p04645]	Subtracted	265.365	242.593	22.772
	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	Divided	203.251	224.633	1.1052
287	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]		266.079	240.758	1.10517
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Subtracted	202.459	225.217	22.758
288	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	Divided	266.078	240.758	1.10517
	syntaxin 10 (syn10). [swissprot;acc:o60499]	Subtracted	257.442	234.691	22.751
289	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	Divided	246.892	272.781	1.10486
	syntaxin 6. [swissprot;acc:o43752]	Subtracted	257.414	234.673	22.741
290	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	Divided	210.064	231.969	1.10428

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.