MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 4941 to 4990 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
1236	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Ranked	219.354	224.699	1.02437
	kinesin family member c3. [refseq;acc:nm_005550]	Squared	26958	30597.1	1.13499
	p10-binding protein. [refseq;acc:nm_024491]	Measured	5594.18	6067.49	1.08461
	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	Rooted	64.9834	67.9275	1.04531
1237	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	Ranked	219.354	224.699	1.02437
	myelin gene expression factor 2. [refseq;acc:nm_016132]	Squared	26039.6	29551.2	1.13486
	tsc22-related inducible leucine zipper protein 2 (tsc-22-like protein thg-1). [swissprot;acc:q9y3q8]	Measured	5873.56	6370.31	1.08457
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	Rooted	62.6895	65.5272	1.04527
1238	60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809]	Squared	23538.3	26712.4	1.13485
	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	Ranked	219.354	224.699	1.02437
	sphingolipid delta 4 desaturase; membrane fatty acid (lipid) desaturase; dihydroceramide desaturase. [refseq;acc:nm_003676]	Measured	5873.56	6370.31	1.08457
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	Rooted	62.6896	65.5272	1.04526
1239	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	Measured	5654.53	6132.76	1.08457
	fuse-binding protein-interacting repressor isoform b; siah binding protein 1; pyrimidine tract binding splicing factor; ro ribonucleoprotein-binding protein 1; poly-u binding splicing factor puf60. [refseq;acc:nm_014281]	Squared	26127.9	29648.4	1.13474
	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]	Ranked	219.354	224.699	1.02437
	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]	Rooted	60.3671	57.7552	1.04522
1240	cytochrome c oxidase assembly protein cox11, mitochondrial precursor. [swissprot;acc:q9y6n1]		62.6939	65.5285	1.04521
	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	Ranked	219.354	224.7	1.02437
	multisynthetase complex auxiliary component p38 (jtv-1 protein) (pro0992). [swissprot;acc:q13155]	Squared	26127.9	29648.4	1.13474
	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Measured	5654.54	6132.69	1.08456
1241	26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]		6436.19	6980.13	1.08451
	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Ranked	219.354	224.7	1.02437
	surfeit locus protein 1. [swissprot;acc:q15526]	Rooted	62.6939	65.5285	1.04521
	yl-1 protein (transcription factor-like 1). [swissprot;acc:q15906]	Squared	26204.1	29732	1.13463
1242	hydroxyacylglutathione hydrolase (ec 3.1.2.6) (glyoxalase ii) (glx ii). [swissprot;acc:q16775]
	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	Ranked	219.354	224.7	1.02437
	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	Rooted	62.6944	65.5286	1.04521
	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Measured	11143.5	10276.3	1.08439
1243	cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	Rooted	62.6939	65.5285	1.04521
	keratin associated protein 1.5. [refseq;acc:nm_031957]	Ranked	219.354	224.699	1.02437
	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	Squared	19239.8	21829.3	1.13459
	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Measured	11143.5	10276.3	1.08439
1244	myofibrillogenesis regulator 1; trans-activated by hepatitis c virus core protein 2; likely ortholog of mouse brain protein 17. [refseq;acc:nm_022572]	Squared	26227.1	29756.6	1.13457
	protoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase). [swissprot;acc:q12887]	Rooted	62.6939	65.5285	1.04521
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	Measured	4835.55	5243.23	1.08431
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Ranked	219.354	224.7	1.02437
1245	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	Measured	4835.55	5243.23	1.08431
	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	Rooted	62.6947	65.5287	1.0452
	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]	Ranked	219.354	224.699	1.02437
	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	Squared	13127	14892.9	1.13452
1246	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	Rooted	62.6947	65.5287	1.0452
	glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712]	Squared	20120.1	22818.6	1.13412
	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	Ranked	219.354	224.699	1.02437
	p53-related protein kinase (ec 2.7.1.-) (nori-2). [swissprot;acc:q96s44]	Measured	5346.11	5796.72	1.08429
1247	glutathione s-transferase theta 1 (ec 2.5.1.18) (gst class-theta) (glutathione transferase t1-1). [swissprot;acc:p30711]	Squared	20117.4	22815.3	1.13411
	inhibitor of growth family, member 1-like; inhibitor of growth 1-like. [refseq;acc:nm_001564]	Rooted	57.8009	55.3045	1.04514
	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	Measured	6278.76	6807.51	1.08421
	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	Ranked	219.354	224.7	1.02437
1248	keratin associated protein 4.4. [refseq;acc:nm_032524]			224.699
	peroxisomal n1-acetyl-spermine/spermidine oxidase. [refseq;acc:nm_152911]	Squared	20118.6	22816.7	1.13411

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.