MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 923 to 972 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
462	large neutral amino acids transporter small subunit 1 (l-type amino acid transporter 1) (4f2 light chain) (4f2 lc) (4f2lc) (cd98 light chain) (integral membrane protein e16) (hlat1). [swissprot;acc:q01650]	Low confidence	201.466	194.819	1.03412
	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	High confidence	254.434	236.224	1.07709
463	dna-directed rna polymerases iii 39 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c39 subunit). [swissprot;acc:q9h1d9]		238.921	257.327	1.07704
	paired mesoderm homeobox protein 1 (prx-1) (paired related homeobox protein 1) (homeobox protein phox1). [swissprot;acc:p54821]	Low confidence	194.41	201.036	1.03408
464	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]	High confidence	210.578	226.764	1.07686
	rna polymerase ii elongation factor ell2. [swissprot;acc:o00472]	Low confidence	198.618	205.369	1.03399
465	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]		207.812	200.994	1.03392
	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	High confidence	248.152	267.226	1.07686
466	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	Low confidence	207.812	200.994	1.03392
467	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	High confidence	248.152	267.226	1.07686
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	Low confidence	207.812	200.994	1.03392
468	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]
	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	High confidence	248.152	267.226	1.07686
469	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]
	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	Low confidence	207.812	200.994	1.03392
470	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	High confidence	248.152	267.226	1.07686
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	Low confidence	198.464	191.96	1.03388
471	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]	High confidence	248.152	267.226	1.07686
	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	Low confidence	208.29	201.499	1.0337
472	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]		201.847	195.283	1.03361
	thymic stromal co-transporter. [refseq;acc:nm_033051]	High confidence	248.152	267.226	1.07686
473	exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]	Low confidence	209.111	202.34	1.03346
	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	High confidence	225.661	209.651	1.07637
474	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]		226.789	210.818	1.07576
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Low confidence	171.213	165.68	1.0334
475	fucosidase, alpha-l- 2, plasma. [refseq;acc:nm_032020]		202.311	195.778	1.03337
	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	High confidence	226.727	210.816	1.07547
476	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]		226.681	210.814	1.07527
	tissue alpha-l-fucosidase precursor (ec 3.2.1.51) (alpha-l-fucosidase i) (alpha-l-fucoside fucohydrolase). [swissprot;acc:p04066]	Low confidence	202.271	195.742	1.03336
477	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]		203.823	197.249	1.03333
	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	High confidence	251.926	234.547	1.0741
478	flavin reductase (ec 1.5.1.30) (fr) (nadph-dependent diaphorase) (nadph-flavin reductase) (flr) (biliverdin reductase b) (ec 1.3.1.24) (bvr-b) (biliverdin-ix beta-reductase) (green heme binding protein) (ghbp). [swissprot;acc:p30043]	Low confidence	207.68	214.591	1.03328
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	High confidence	228.051	212.321	1.07409
479	nucleolar protein family a, member 1; gar1 protein. [refseq;acc:nm_018983]
	protein c6orf55 (dopamine responsive protein drg-1) (my012 protein) (hspc228). [swissprot;acc:q9np79]	Low confidence	207.68	214.591	1.03328
480	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	High confidence	237.109	254.667	1.07405
	ns1-associated protein 1. [refseq;acc:nm_006372]	Low confidence	203.822	197.259	1.03327
481	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	High confidence	237.109	254.667	1.07405
	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	Low confidence	171.564	166.045	1.03324
482	heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	High confidence	237.109	254.667	1.07405
	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	Low confidence	204.65	198.086	1.03314
483	rna-binding protein. [refseq;acc:nm_019027]		203.821	197.289	1.03311
	runt-related transcription factor 2 (core-binding factor, alpha 1 subunit) (cbf-alpha 1) (acute myeloid leukemia 3 protein) (oncogene aml-3) (polyomavirus enhancer binding protein 2 alpha a subunit) (pebp2-alpha a) (pea2-alpha a) (sl3-3 enhancer factor 1 alpha a subunit) (sl3/akv core-binding factor alpha a subunit) (osteoblast- specific transcription factor 2) (osf-2). [swissprot;acc:q13950]	High confidence	237.109	254.667	1.07405
484	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Low confidence	203.821	197.291	1.0331
	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	High confidence	237.109	254.667	1.07405
485	60s ribosomal protein l18. [swissprot;acc:q07020]
	tubulin tyrosine ligase-like protein hottl (hqp0207). [swissprot;acc:q9y4r7]	Low confidence	205.109	198.551	1.03303
486	chromosome x open reading frame 9; likely ortholog of mouse sh3 gene sly. [refseq;acc:nm_018990]		204.331	211.075	1.03301
	mct-1 protein. [refseq;acc:nm_014060]	High confidence	226.313	243.03	1.07387

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.