MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	Value Type	Rank	Gene	description	green	Interaction Map	Network Comparison Type	red	network_comparison

Results: HTML CSV LaTeX

Showing element 3180 to 3229 of 19268 in total

Filtered  : 1
Value Type  : Ranked

Rank	description	green	Interaction Map	Network Comparison Type	red	network_comparison
123	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	190.094	Low confidence	Divided	202.96	1.06768
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	193.056	High confidence	Subtracted	227.032	33.976
	striatin. [swissprot;acc:o43815]	200.796	Low confidence		214.085	13.289
124	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	206.997			220.268	13.271
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	171.595	High confidence	Divided	208.52	1.21519
	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	210.566	Low confidence		224.763	1.06742
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	252.234	High confidence	Subtracted	285.684	33.45
125	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	227.616	Low confidence	Divided	213.243	1.0674
	high-mobility group 20a. [refseq;acc:nm_018200]	171.778	High confidence		208.588	1.21429
	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	206.997	Low confidence	Subtracted	220.268	13.271
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	252.234	High confidence		285.684	33.45
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	114		Divided	94	1.21277
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	252.234		Subtracted	285.684	33.45
	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	179.639	Low confidence	Divided	191.688	1.06707
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	213.661		Subtracted	226.892	13.231
127	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	235.538			222.31	13.228
	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	252.234	High confidence		285.684	33.45
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	114		Divided	94	1.21277
	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	190.88	Low confidence		203.678	1.06705
128	adenomatous polyposis coli like. [refseq;acc:nm_005883]	235.547		Subtracted	222.34	13.207
	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	114	High confidence	Divided	94	1.21277
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	252.234		Subtracted	285.684	33.45
	striatin. [swissprot;acc:o43815]	200.796	Low confidence	Divided	214.085	1.06618
129	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	252.234	High confidence	Subtracted	285.684	33.45
	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	235.572	Low confidence	Divided	220.969	1.06609
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	114	High confidence		94	1.21277
	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	205.431	Low confidence	Subtracted	218.561	13.13
130	neuronal protein np25. [swissprot;acc:q9ui15]	205.57			218.66	13.09
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	276.059	High confidence		242.735	33.324
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	114		Divided	94	1.21277
	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	211.529	Low confidence		225.495	1.06602
131	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	276.018	High confidence	Subtracted	242.718	33.3
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	242.562		Divided	294.053	1.21228
	striatin 4 (zinedin). [swissprot;acc:q9nrl3]	200.825	Low confidence		213.878	1.065
				Subtracted		13.053
132	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	206.997		Divided	220.268	1.06411
	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	196.695	High confidence	Subtracted	229.406	32.711
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	189.965	Low confidence		203.016	13.051
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	290	High confidence	Divided	350	1.2069
133	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	194.72		Subtracted	226.887	32.167
	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	206.997	Low confidence	Divided	220.268	1.06411
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	189.985		Subtracted	203.007	13.022
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	290	High confidence	Divided	350	1.2069
134	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	194.79		Subtracted	226.884	32.094
	transgelin (smooth muscle protein 22-alpha) (sm22-alpha) (ws3-10) (22 kda actin-binding protein). [swissprot;acc:q01995]	205.431	Low confidence	Divided	218.561	1.06391
	transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]	205.4		Subtracted	218.36	12.96
135	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	290	High confidence	Divided	350	1.2069
	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	231.407		Subtracted	263.215	31.808
	neuronal protein np25. [swissprot;acc:q9ui15]	205.57	Low confidence	Divided	218.66	1.06368

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.