MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 530 to 579 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	Network Comparison Type	red	green	network_comparison
67	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Measured	Divided	6475.5	10307.5	1.59177
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Squared	Subtracted	144876	81136.5	63739.5
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Ranked	Divided	267.14	336.075	1.25805
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Squared		219048	129762	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Rooted		63.8686	47.2654	1.35128
	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	Measured	Subtracted	17756.5	14007.3	3749.2
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	Ranked		187.458	243.677	56.219
68	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Measured	Divided	6475.5	10307.5	1.59177
	cyclin g2. [swissprot;acc:q16589]		Subtracted	17738.6	13995.7	3742.9
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Squared		139741	78454.6	61286.4
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Rooted		63.8686	47.2654	16.6032
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]		Divided			1.35128
	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Ranked		267.139	336.075	1.25805
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Squared		219048	129762	1.68808
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	Ranked	Subtracted	187.462	243.673	56.211
69	cyclin g1 (cyclin g). [swissprot;acc:p51959]	Measured		17738.5	13995.6	3742.9
	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Rooted		63.8686	47.2654	16.6032
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Ranked	Divided	267.14	336.075	1.25805
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Squared		219048	129762	1.68808
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Ranked	Subtracted	284.753	228.934	55.819
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	Rooted	Divided	27.9136	37.2872	1.33581
	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	Squared	Subtracted	178263	118639	59624
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Measured	Divided	6475.5	10307.5	1.59177
70	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	Rooted		27.9136	37.2872	1.33581
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Squared	Subtracted	129597	73157.5	56439.5
	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	Ranked	Divided	267.142	336.074	1.25804
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Squared		219048	129762	1.68808
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Rooted	Subtracted	63.8686	47.2654	16.6032
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Measured		17738.5	13995.7	3742.8
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	Ranked		188.688	242.742	54.054
71	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Squared		129597	73157.5	56439.5
	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	Rooted	Divided	27.9136	37.2872	1.33581
	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]		Subtracted	63.8686	47.2654	16.6032
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	Ranked	Divided	267.144	336.073	1.25802
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]		Subtracted	265.686	319.651	53.965
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Squared	Divided	219048	129762	1.68808
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Measured		4556.78	2945.26	1.54716
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]		Subtracted	17738.5	13995.7	3742.8
72	44050 protein. [refseq;acc:nm_178832]	Squared		148058	99628.4	48429.6
	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]	Measured		17710.9	13977.7	3733.2
	deltex 2. [refseq;acc:nm_020892]	Rooted		27.634	43.9629	16.3289
	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Ranked	Divided	267.144	336.073	1.25802
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Squared		219048	129762	1.68808
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Rooted		27.9136	37.2872	1.33581
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Ranked	Subtracted	265.639	319.546	53.907
	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	Measured	Divided	4556.79	2945.28	1.54715
73	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	Rooted	Subtracted	27.7078	44.017	16.3092
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Ranked	Divided	288	362	1.25694
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]		Subtracted	265.632	319.531	53.899

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.