MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1130 to 1179 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	network_comparison	green
cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]	832	no value	Divided	231.734	1.0428	222.222
cgthba protein (-14 gene protein). [swissprot;acc:q12980]	592	C16orf35	Subtracted	217.67	12.926	230.596
	644		Divided		1.05938
channel associated protein of synapse-110 (chapsyn-110) (discs, large homolog 2). [swissprot;acc:q15700]	2647	DLG2	Subtracted	216.934	0.234	216.7
	2657		Divided		1.00108
chaperone-activity of bc1 complex-like, mitochondrial precursor (chaperone-abc1-like). [swissprot;acc:q8ni60]	1726	CABC1	Subtracted	215.336	2.769	212.567
	1730		Divided		1.01303
choline dehydrogenase. [refseq;acc:nm_018397]	1647	CHDH		217.256	1.01451	214.149
	1654		Subtracted		3.107
choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	1936	CHAT		211.632	2.07	213.702
	1967		Divided		1.00978
cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	189	PCYT1A	Subtracted	241.373	25.979	267.352
	269		Divided		1.10763
cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	195	PCYT1B	Subtracted		25.979
	275		Divided		1.10763
chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	139	CHRAC1	Subtracted	287.41	30.575	256.835
	234		Divided		1.11905
chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	240	RBBP4	Subtracted	252.39	24.093	228.297
	282		Divided		1.10553
chromatin-specific transcription elongation factor large subunit. [refseq;acc:nm_007192]	838	SUPT16H	Subtracted	237.62	8.858	228.762
	902		Divided		1.03872
chromobox protein homolog 1 (heterochromatin protein 1 homolog beta) (hp1 beta) (modifier 1 protein) (m31) (heterochromatin protein p25). [swissprot;acc:p23197]	2535	CBX1		188.228	1.00214	188.63
	2541		Subtracted		0.402
chromobox protein homolog 3 (heterochromatin protein 1 homolog gamma) (hp1 gamma) (modifier 2 protein) (hech). [swissprot;acc:q13185]	2509	CBX3	Divided	187.902	1.00247	188.366
	2530		Subtracted		0.464
chromobox protein homolog 5 (heterochromatin protein 1 homolog alpha) (hp1 alpha) (antigen p25). [swissprot;acc:p45973]	2505	CBX5	Divided	187.853	1.00252	188.326
	2525		Subtracted		0.473
chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	168	CHD5		312	28	284
	335		Divided		1.09859
chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	158	CHD3	Subtracted		28
	330		Divided		1.09859
chromodomain protein, y chromosome-like isoform a; cdy-like, autosomal; testis-specific chromodomain y-like protein. [refseq;acc:nm_004824]	2553	CDYL		193.12	1.0018	193.467
	2569		Subtracted		0.347
chromodomain y-like protein 2. [refseq;acc:nm_152342]	2556	CDYL2	Divided	193.119	1.00177	193.46
	2573		Subtracted		0.341
chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	1174	C11orf2		214.364	5.395	219.759
	1211		Divided		1.02517
chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	87	RBM15B	Subtracted	249.663	48.6	298.263
	153		Divided		1.19466
cirhin; testis expressed gene 292; cirrhosis, autosomal recessive 1a. [refseq;acc:nm_032830]	904	CIRH1A	Subtracted	243.312	7.961	235.351
	982		Divided		1.03383
cisplatin resistance related protein crr9p. [refseq;acc:nm_030782]	3197	CLPTM1L		0.00001	1	0.00001
			Subtracted	0	0	0
clathrin coat assembly protein ap180 (clathrin coat associated protein ap180) (91 kda synaptosomal-associated protein). [swissprot;acc:o60641]	1339	SNAP91		218.471	4.595	213.876
	1392		Divided		1.02148
clathrin coat assembly protein ap50 (clathrin coat associated protein ap50) (plasma membrane adaptor ap-2 50 kda protein) (ha2 50 kda subunit) (clathrin assembly protein complex 2 medium chain) (ap-2 mu 2 chain). [swissprot;acc:p20172]	2208	AP2M1		199.129	1.00645	200.413
	2231		Subtracted		1.284
clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]	394	CLTC		207.889	18.337	226.226
	399		Divided		1.08821
clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	400	CLTCL1	Subtracted	207.931	18.278	226.209

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.