MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	Network Comparison Type	description	Interaction Map	Filtered	network_comparison	red	green

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Showing element 451 to 500 of 66312 in total

Filtered  : 1

Rank	Value Type	Hugo	Network Comparison Type	description	Interaction Map	network_comparison	red	green
29	Measured	SEPT10	Subtracted	septin 10 isoform 1. [refseq;acc:nm_144710]	Low confidence	1791.4	13081.2	14872.6
		TOB1	Divided	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]		1.19818	3121.28	3739.84
	Ranked	ATF3		cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		1.19089	203.115	170.557
		CHRAC1	Subtracted	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]		32.401	250.244	217.843
		GNAZ		guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	68.936	267.139	336.075
		PPP2R2D	Divided	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]		1.29991	187.458	243.678
	Squared	CHD5		chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]		3.18404	143.692	457.521
		MAGED2	Subtracted	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]		89286	219048	129762
		MAGEE2	Divided	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Low confidence	1.33073	82347.8	61881.5
		PSCD2	Subtracted	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		21128.1	92930.5	71802.4
	Rooted	CPEB3	Divided	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]		1.16077	48.8531	56.7071
		PPP1R14A		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	High confidence	1.65937	26.0288	43.1914
		UBAC1	Subtracted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		18.763	210.928	192.165
		UBR4		retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Low confidence	12.051	76.5734	88.6244
30	Measured	BEST1	Divided	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]		1.19288	36474.3	43509.4
		GNG5		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	High confidence	2.04837	1834.59	895.633
		MAGEF1	Subtracted	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		5430.7	23693.7	18263
		PIGF		phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	Low confidence	1780.5	3278	5058.5
	Ranked	no value	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	High confidence	1.29991	187.457	243.678
		BOK		bcl2-related ovarian killer. [refseq;acc:nm_032515]	Low confidence	1.18995	265.638	223.235
		GNAT2	Subtracted	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	68.935	267.14	336.075
		SON		son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Low confidence	31.844	255.382	223.538
	Squared	no value	Divided	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		1.33073	82347.8	61881.5
			Subtracted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		21127.9	92930	71802.1
		CDK2AP1	Divided	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	High confidence	3.18404	143.692	457.521
		TRO	Subtracted	trophinin. [swissprot;acc:q12816]		89286	219048	129762
	Rooted	ATF3		cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		18.7077	60.8022	79.5099
		CPEB4	Divided	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Low confidence	1.16055	48.8781	56.7253
		MFAP4		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	High confidence	1.65937	26.0288	43.1914
		PRKRAP1	Subtracted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Low confidence	11.5202	44.4168	55.937
31	Measured	BEST4	Divided	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]		1.19287	36469.3	43503.3
		GNG10		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	2.04827	1834.63	895.697
		MAGEB6B	Subtracted	melanoma antigen, family b, 6. [refseq;acc:nm_173523]		5430.7	23693.7	18263
		TUSC3		n33 protein. [swissprot;acc:q13454]	Low confidence	1780.5	3278	5058.5
	Ranked	no value		atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		28	142	170
		DNASE2B	Divided	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]		1.17568	57.395	48.8186
		GNAT1	Subtracted	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	High confidence	68.935	267.14	336.075
		PPP2R2B	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]		1.2999	187.458	243.677
	Squared	ARRB2		beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		2.53372	9924.76	25146.6
		MAGEA11		melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Low confidence	1.33073	82347.8	61881.5
		MRPS17	Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	High confidence	85915	106226	192141
		PSCD3		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Low confidence	21124	92920.4	71796.4
	Rooted	HINT1		histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		10.8344	67.7094	56.875
		MRPS17	Divided	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		1.1597	145.551	168.796
		PPP1R14D		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	High confidence	1.65937	26.0288	43.1914
		UFC1	Subtracted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		18.7028	40.0958	58.7986
32	Measured	no value	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		2.04793	1834.73	895.893
				nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Low confidence	1.19275	36360.3	43368.8
			Subtracted	implantation-associated protein. [refseq;acc:nm_032121]		1780.5	3278	5058.5
				melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	High confidence	5430.7	23693.7	18263

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.