MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1362 to 1411 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
341	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Measured	20446.1	24136.4	1.18049
	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	Rooted	51.9812	57.5858	1.10782
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	Squared	32056.4	39965.8	1.24673
342	40s ribosomal protein s20. [swissprot;acc:p17075]	Ranked	243.5	267.21	1.09737
	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	Squared	70830.5	56822	1.24653
	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Measured	20446.1	24136.4	1.18049
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	Rooted	49.2715	54.5757	1.10765
343	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]		50.3169	45.4333	1.10749
	conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]	Squared	70830.5	56822	1.24653
	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Measured	20446.1	24136.4	1.18049
	protein arginine n-methyltransferase 3 (ec 2.1.1.-) (fragment). [swissprot;acc:o60678]	Ranked	241.625	265.136	1.0973
344	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Measured	20446.1	24136.4	1.18049
	isocitrate dehydrogenase [nadp], mitochondrial precursor (ec 1.1.1.42) (oxalosuccinate decarboxylase) (idh) (nadp+-specific icdh) (idp) (icd-m). [swissprot;acc:p48735]	Squared	37226.9	46400.1	1.24641
	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	Rooted	49.4233	54.7327	1.10743
345	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]		56.2615	62.2958	1.10725
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Measured	20446.1	24136.4	1.18049
	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	Squared	35793	44595.3	1.24592
	ump-cmp kinase (ec 2.7.4.14) (cytidylate kinase) (deoxycytidylate kinase) (cytidine monophosphate kinase). [swissprot;acc:p30085]	Ranked	242.14	265.697	1.09729
346	40s ribosomal protein s3. [swissprot;acc:p23396]		241.612	265.119
	grb2-related adaptor protein. [swissprot;acc:q13588]	Rooted	61.4282	68.0107	1.10716
	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	Squared	34018.3	42373	1.24559
	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Measured	14229.2	16780.7	1.17931
347	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	Rooted	66.4284	60.0004	1.10713
	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	Measured	4991.02	5885.09	1.17914
	gtp:amp phosphotransferase mitochondrial (ec 2.7.4.10) (ak3) (adenylate kinase 3 alpha like 1). [swissprot;acc:q9uij7]	Ranked	242.14	265.697	1.09729
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Squared	16573.6	20637.8	1.24522
348	ad24 protein. [refseq;acc:nm_022451]	Rooted	49.2558	54.5235	1.10695
	adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	Ranked	242.14	265.696	1.09728
	golgi reassembly stacking protein 2; golgi reassembly stacking protein 2, 55 kda. [refseq;acc:nm_015530]	Squared	42566.2	52985.3	1.24477
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	Measured	4991.02	5885.09	1.17914
349	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]		4714.85	5554.38	1.17806
	sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962]	Squared	35533.9	44227	1.24464
	surfeit locus protein 5. [swissprot;acc:q15528]	Ranked	242.14	265.696	1.09728
	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Rooted	56.0061	61.9704	1.10649
350	armet protein precursor (arginine-rich protein). [swissprot;acc:p55145]	Squared	35508.7	44191.4	1.24452
	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	Rooted	61.3383	67.8668	1.10643
	sedlin. [swissprot;acc:o14582]	Measured	17396.9	20483.9	1.17745
	zinc finger protein 291. [swissprot;acc:q9by12]	Ranked	242.14	265.696	1.09728
351	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	Rooted	61.3352	67.8618	1.10641
	histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	Squared	35508.6	44191.3	1.24452
	peroxisome biogenesis factor 1 (peroxin-1) (peroxisome biogenesis disorder protein 1). [swissprot;acc:o43933]	Ranked	242.14	265.696	1.09728
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Measured	17396.9	20483.9	1.17745
352	40s ribosomal protein s28. [swissprot;acc:p25112]	Squared	30682.9	38183.6	1.24446
	bet3 homolog. [swissprot;acc:o43617]	Measured	17396.9	20483.9	1.17745
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Rooted	61.3354	67.8621	1.10641
	protein 1-4 (atp binding protein associated with cell differentiation). [swissprot;acc:o14530]	Ranked	242.14	265.696	1.09728
353	54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233]	Squared	71383	57399.3	1.24362
	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Rooted	61.3354	67.8623	1.10641
	p66 alpha. [refseq;acc:nm_017660]	Measured	12839	10911.1	1.17669

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.