MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 923 to 972 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
231	Squared	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	137.446	120.823	1.13758
232	Measured	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	9035	7279.6	1.24114
	Ranked	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	239.336	267.879	1.11926
	Squared	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	137.446	120.823	1.13758
233	Measured	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	9035	7279.6	1.24114
	Ranked	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	239.32	267.842	1.11918
	Squared	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	42411.6	55802.1	1.31573
	Rooted	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	137.446	120.823	1.13758
234	Measured	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	5181.2	6410.58	1.23728
	Ranked	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	287.41	256.835	1.11905
	Squared	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	137.446	120.823	1.13758
235	Measured	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	5181.2	6410.58	1.23728
	Ranked	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	227.357	254.15	1.11785
	Squared	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	137.446	120.823	1.13758
236	Measured	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	4723.53	5828.46	1.23392
	Ranked	pp3111 protein. [refseq;acc:nm_022156]	227.357	254.15	1.11785
	Squared	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	137.446	120.823	1.13758
237	Measured	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	4567.04	5631.2	1.23301
	Ranked	syntaxin 18. [swissprot;acc:q9p2w9]	227.357	254.15	1.11785
	Squared	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	137.446	120.823	1.13758
238	Measured	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	27642.5	22440.4	1.23182
	Ranked	rd protein. [swissprot;acc:p18615]	227.357	254.15	1.11785
	Squared	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	137.446	120.823	1.13758
239	Measured	carboxypeptidase b precursor. [refseq;acc:nm_020361]	7711.38	6265.8	1.23071
	Ranked	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	227.357	254.15	1.11785
	Squared	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	137.446	120.823	1.13758
240	Measured	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	7711.36	6265.79	1.23071
	Ranked	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	227.357	254.15	1.11785
	Squared	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	137.446	120.823	1.13758
241	Measured	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	7711.31	6265.76	1.23071
	Ranked	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	227.357	254.15	1.11785
	Squared	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	137.446	120.823	1.13758
242	Measured	max protein. [swissprot;acc:p25912]	4640.26	5704.87	1.22943
	Ranked	j domain containing protein 1. [swissprot;acc:q9ukb3]	227.357	254.15	1.11785
	Squared	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	42411.6	55802.1	1.31573
	Rooted	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	137.446	120.823	1.13758
243	Measured	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	4246.95	5208.98	1.22652
	Ranked	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	227.357	254.15	1.11785
	Squared	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	42411.6	55802.1	1.31573
	Rooted	trophinin. [swissprot;acc:q12816]	137.446	120.823	1.13758

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.