MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Rank	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1225 to 1274 of 29840 in total

Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Network Comparison Type	Filtered	red	green	network_comparison
307	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Subtracted	1	7556.75	8636.87	1080.12
	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]		0	292.152	378.206	86.054
	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	Divided		4159.87	3775.43	1.10183
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]		1	12365.2	14824.9	1.19892
308	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	Subtracted		11852.9	10773.5	1079.4
	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]		0	291.639	377.574	85.935
	neurocalcin delta. [swissprot;acc:p29554]	Divided		702.055	773.218	1.10136
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]		1	4977.09	5966.44	1.19878
309	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	Subtracted		11848.8	10770.3	1078.5
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]		0	260.986	346.751	85.765
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Divided	1	4977.8	5966.14	1.19855
	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]		0	1890.86	2081.91	1.10104
310	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Subtracted	1	7551.8	8630.06	1078.26
	integral membrane protein cii-3b. [sptrembl;acc:o75609]		0	2218.63	2304.22	85.59
	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]	Divided		4755.32	4320.09	1.10075
	squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146]		1	4909.79	5878.79	1.19736
311	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Subtracted		2820.51	3897.1	1076.59
	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]		0	470.251	384.733	85.518
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Divided	1	4981.52	5964.58	1.19734
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]		0	3117.17	2833.94	1.09994
312	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]			3455.43	3800.29	1.0998
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Subtracted		287.903	372.961	85.058
	max protein. [swissprot;acc:p25912]		1	4640.26	5704.87	1064.61
	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	Divided		4598.21	5500.48	1.19622
313	60s acidic ribosomal protein p1. [swissprot;acc:p05386]		0	6131.07	6739.34	1.09921
	60s ribosomal protein l18a. [swissprot;acc:q02543]	Subtracted		2688.7	2604.71	83.99
	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	Divided	1	21644.2	18098.7	1.1959
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Subtracted		4567.04	5631.2	1064.16
314	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]		0	252	335	83
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]		1	6563.65	7627.29	1063.64
	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	Divided		21632.5	18090	1.19583
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]		0	5302.7	4827.7	1.09839
315	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]			1212.82	1104.61	1.09796
	5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196]	Subtracted		726.245	808.929	82.684
	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	Divided	1	21370.8	17896.5	1.19413
	vav proto-oncogene. [swissprot;acc:p15498]	Subtracted		6644.99	7707.8	1062.81
316	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	Divided	0	525	576	1.09714
	ero1-like. [refseq;acc:nm_014584]	Subtracted		82	0	82
	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	Divided	1	21370.8	17896.5	1.19413
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Subtracted		6603.41	7664.65	1061.24
317	adiponectin receptor 2. [refseq;acc:nm_024551]	Divided		3153.1	3762.56	1.19329
	my016 protein. [sptrembl;acc:q9h3k6]		0	1770.21	1615.47	1.09579
	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Subtracted		72	151	79
	vav-3 protein. [swissprot;acc:q9ukw4]		1	6647.43	7706.18	1058.75
318	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]			7485.08	8543.66	1058.58
	importin 7; ran-binding protein 7. [refseq;acc:nm_006391]		0	191.333	115.333	76
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	1	34190.9	40795.8	1.19318
	protein cgi-147. [swissprot;acc:q9y3e5]		0	8396.12	9192.38	1.09484
319	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Subtracted	1	7477	8532.02	1055.02
	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	Divided	0	1388.45	1268.19	1.09483

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.