MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1875 to 1924 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
938	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Subtracted	205.087	212.442	7.355
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Divided	212.618	220.246	1.03588
939	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]		224.27	216.501
	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	Subtracted	205.085	212.44	7.355
940	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	Divided	205.088	212.442	1.03586
		Subtracted			7.354
941	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	Divided	205.083	212.437	1.03586
		Subtracted			7.354
942	grancalcin. [swissprot;acc:p28676]	Divided	205.088	212.442	1.03586
		Subtracted			7.354
943	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]		205.083	212.437
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Divided	205.087	212.442	1.03586
944	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Subtracted	205.191	212.51	7.319
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	Divided	205.083	212.437	1.03586
945	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]		205.085	212.44
	dihydropyrimidine dehydrogenase [nadp+] precursor (ec 1.3.1.2) (dpd) (dhpdhase) (dihydrouracil dehydrogenase) (dihydrothymine dehydrogenase). [swissprot;acc:q12882]	Subtracted	221.823	229.116	7.293
946	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]		218.271	225.557	7.286
	histone h4. [swissprot;acc:p02304]	Divided	219.902	227.765	1.03576
947	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]		205.191	212.51	1.03567
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	Subtracted	170.499	177.776	7.277
948	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]		217.922	225.167	7.245
	target of myb protein 1. [swissprot;acc:o60784]	Divided	209.824	217.254	1.03541
949	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]		209.826	217.253	1.0354
	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]	Subtracted	217.922	225.167	7.245
950	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	Divided	261.821	252.873	1.03539
	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	Subtracted	217.922	225.167	7.245
951	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	Divided	209.827	217.253	1.03539
952	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	Subtracted	218.232	225.448	7.216
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	Divided	209.83	217.252	1.03537
953	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	Subtracted	170.82	178.033	7.213
	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	Divided	205.466	198.494	1.03512
954	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]		276.773	267.447	1.03487
	thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541]	Subtracted	235.609	228.412	7.197
955	bai1-associated protein 1; ww domain-containing protein 3; atrophin-1 interacting protein 3. [refseq;acc:nm_004742]		228.906	221.73	7.176
	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	Divided	239.205	231.163	1.03479
956	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	Subtracted	128.225	135.379	7.154
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	Divided	204.732	211.812	1.03458
957	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]		134.399	129.913	1.03453
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Subtracted	161.452	168.592	7.14
958	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	Divided	134.406	129.921	1.03452
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Subtracted	211.338	218.459	7.121
959	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	Divided	229.677	237.558	1.03431
	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	Subtracted	211.343	218.461	7.118
960	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]		211.345	218.462	7.117
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	Divided	229.677	237.558	1.03431
961	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	Subtracted	211.357	218.468	7.111
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Divided	134.527	130.066	1.0343
962	cyclin g2. [swissprot;acc:q16589]
	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	Subtracted	212.547	219.656	7.109

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.