MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 451 to 500 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	red	green	network_comparison
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	2321	PSMC2	Divided	Ranked	Low confidence	198.366	194.732	1.01866
	2394		Subtracted		High confidence	218.192	219.014	0.822
	2395		Divided					1.00377
	2407		Subtracted		Low confidence	198.366	194.732	3.634
	4819			Squared		47959.2	47560.6	398.6
	4841		Divided					1.00838
26s protease regulatory subunit 8 (proteasome subunit p45) (thyroid hormone receptor interacting protein 1) (trip1) (msug1 protein) (tat-binding protein homolog 10) (tbp10) (p45/sug). [swissprot;acc:p47210]	453	PSMC5	Subtracted		High confidence	59318.4	53788.1	5530.3
	797				Low confidence	46535.2	44326.9	2208.3
	864		Divided					1.04982
	1637			Ranked	High confidence	202.358	199.408	1.01479
	1682		Subtracted					2.95
	1721		Divided	Squared		59318.4	53788.1	1.10282
	1772		Subtracted	Rooted		74.9362	76.9113	1.9751
	2059		Divided					1.02636
	2149		Subtracted	Ranked	Low confidence	200.982	197.22	3.762
	2163		Divided					1.01908
	2260		Subtracted	Rooted		72.3171	74.792	2.4749
	2297		Divided					1.03422
	2602		Subtracted	Measured	High confidence	9150.44	9234.09	83.65
	2651		Divided					1.00914
	2944		Subtracted		Low confidence	8088.94	8314.51	225.57
	3044		Divided					1.02789
26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [swissprot;acc:q92524]	1280	PSMC6	Subtracted	Squared	High confidence	27176.8	30113.9	2937.1
	1577		Divided	Measured		5923.66	6349.04	1.07181
	1599		Subtracted					425.38
	1630		Divided	Squared		27176.8	30113.9	1.10807
	1944			Rooted		62.7515	64.5421	1.02853
	1968		Subtracted					1.7906
	2478		Divided	Ranked		216.177	216.801	1.00289
	2486		Subtracted					0.624
	2526			Measured	Low confidence	8088.12	8326.51	238.39
	2711		Divided					1.02947
	3092		Subtracted	Rooted		72.5509	74.8438	2.2929
	3167		Divided					1.0316
	3429		Subtracted	Squared		45773.6	44345.7	1427.9
	3515		Divided	Ranked		200.312	197.374	1.01489
	3521		Subtracted					2.938
	3537		Divided	Squared		45773.6	44345.7	1.0322
26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	830	PSMD1	Subtracted	Ranked		204.36	199.229	5.131
	857		Divided					1.02575
	1146			Squared		44506	42544.1	1.04611
	1162			Rooted		70.8788	73.5808	1.03812
	1182		Subtracted	Squared	High confidence	26860.7	29969	3108.3
	1280			Rooted	Low confidence	70.8788	73.5808	2.702
	1379			Squared		44506	42544.1	1961.9
	1476		Divided		High confidence	26860.7	29969	1.11572
	1862		Subtracted	Measured		5826	6195.48	369.48
	1883		Divided					1.06342
	2129			Rooted		62.0038	63.5033	1.02418
	2140		Subtracted					1.4995

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.